Histological and ultrastructural alterations of rat thyroid gland after short-term treatment with high doses of thyroid hormones
Joint Authors
Rajab, Njia M. Ali
Ukropina, Mirela
Cakic Milosevic, Maja
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 6 (30 Sep. 2017), pp.1117-1125, 9 p.
Publisher
Publication Date
2017-09-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
The aim of the present study was to investigate histological alterations of rat thyroid gland after short-term treatment with supraphysiological doses of thyroid hormones.
Rats from experimental groups were treated with triiodothyronine (T3) or thyroxine (T4) during five days.
In both treated groups, thyrocyte height was reduced and follicular lumens were distended.
Progressive involutive changes of the thyroid parenchyma were apparent, including follicular remodeling (fusion) and death of thyrocytes.
Morphological changes confirmed by quantitative analysis were more pronounced in the T4-treated group.
Our results demonstrate that thyrotoxicosis, whether induced by T3 or T4, leads to different grades of thyroid tissue injury, including some irreversible damages.
These changes might be explained at least in part by lack of trophic and cytoprotective effects of the thyroid stimulating hormone.
Since the period required for morphophysiological recovery may be unpredictable, findings presented here should be taken into consideration in cases where the thyroid hormones are used as a treatment for thyroid and non-thyroid related conditions.
American Psychological Association (APA)
Rajab, Njia M. Ali& Ukropina, Mirela& Cakic Milosevic, Maja. 2017. Histological and ultrastructural alterations of rat thyroid gland after short-term treatment with high doses of thyroid hormones. Saudi Journal of Biological Sciences،Vol. 24, no. 6, pp.1117-1125.
https://search.emarefa.net/detail/BIM-776438
Modern Language Association (MLA)
Rajab, Njia M. Ali…[et al.]. Histological and ultrastructural alterations of rat thyroid gland after short-term treatment with high doses of thyroid hormones. Saudi Journal of Biological Sciences Vol. 24, no. 6 (Sep. 2017), pp.1117-1125.
https://search.emarefa.net/detail/BIM-776438
American Medical Association (AMA)
Rajab, Njia M. Ali& Ukropina, Mirela& Cakic Milosevic, Maja. Histological and ultrastructural alterations of rat thyroid gland after short-term treatment with high doses of thyroid hormones. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 6, pp.1117-1125.
https://search.emarefa.net/detail/BIM-776438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1124-1125
Record ID
BIM-776438