Evaluation of chemical composition and antiedematogenic activity of the essential oil of Hyptis martiusii Benth

Abstract EN

Evaluations of the therapeutic potential of medicinal plants and their components have been the subject of many studies.

Furthermore, the biological activities of various plant species have been reported in various pieces of literature.

Hyptis martiusii Benth (Lamiaceae), popularly known as ‘‘mad balm” is commonly found in the North, Southeast, and Northeast of Brazil.

Its leaves are used ethnobiologically as antiulcerogenic, antimicrobial, antitumor and as insecticide.

This study aimed to analyze the chemical composition of the essential oil of H.

martiusii Benth (OEHM) by GC/MS as well as its possible topical activity as an antiedematogenic.

This is verified by the models of ear edema induced by single (acute edema) and multiple (chronic edema) applications of croton oil topically, and systemically verified through the model of paw edema induced by carrageenan 1%.

Doses of 50, 75 and 100 mg/kg OEHM were used in all tests.

Chemical analysis of the oil revealed the 1,8-cineole (34.58%) and d-carene (21:58%) as major components present in the