Binding of small molecules at interface of protein-protein complex : a newer approach to rational drug design
Joint Authors
Bhattacharjee, A.
Gurung, A. B.
al-Himaid, F.
Lee, Joongku
Ali, M. Ajmal
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 2 (28 Feb. 2017), pp.379-388, 10 p.
Publisher
Publication Date
2017-02-28
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Protein–protein interaction is a vital process which drives many important physiological processes in the cell and has also been implicated in several diseases.
Though the protein–protein interaction network is quite complex but understanding its interacting partners using both in silico as well as molecular biology techniques can provide better insights for targeting such interactions.
Targeting protein–protein interaction with small molecules is a challenging task because of druggability issues.
Nevertheless, several studies on the kinetics as well as thermodynamic properties of protein–protein interactions have immensely contributed toward better understanding of the affinity of these complexes.
But, more recent studies on hot spots and interface residues have opened up new avenues in the drug discovery process.
This approach has been used in the design of hot spot based modulators targeting protein–protein interaction with the objective of normalizing such interactions.
American Psychological Association (APA)
Gurung, A. B.& Bhattacharjee, A.& Ali, M. Ajmal& al-Himaid, F.& Lee, Joongku. 2017. Binding of small molecules at interface of protein-protein complex : a newer approach to rational drug design. Saudi Journal of Biological Sciences،Vol. 24, no. 2, pp.379-388.
https://search.emarefa.net/detail/BIM-776446
Modern Language Association (MLA)
Lee, Joongku…[et al.]. Binding of small molecules at interface of protein-protein complex : a newer approach to rational drug design. Saudi Journal of Biological Sciences Vol. 24, no. 2 (Feb. 2017), pp.379-388.
https://search.emarefa.net/detail/BIM-776446
American Medical Association (AMA)
Gurung, A. B.& Bhattacharjee, A.& Ali, M. Ajmal& al-Himaid, F.& Lee, Joongku. Binding of small molecules at interface of protein-protein complex : a newer approach to rational drug design. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 2, pp.379-388.
https://search.emarefa.net/detail/BIM-776446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 386-388
Record ID
BIM-776446