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In vitro alpha-amylase inhibition and in vivo antioxidant potential of Momordica dioica seeds in streptozotocin-induced oxidative stress in diabetic rats
Joint Authors
Rao, P. Sailaja
Mohan, G. Krishna
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 6 (30 Sep. 2017), pp.1262-1267, 6 p.
Publisher
Publication Date
2017-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Momordica dioica Roxb.
Commonly known as ‘‘Kakora” in Telugu, is used in the Indian traditional system of medicine for the treatment of diabetes.
The aim of this study was to investigate the antidiabetic activity of methanolic extract of M.
dioica seeds (MEMD) in streptozotocin (STZ) induced diabetic rats.
The in vitro a-amylase inhibitory activity of the MEMD was done by spectrophotometric method.
Diabetes was induced by STZ (45 mg / kg ; i.p), MEMD (100 and 200 mg / kg; b.wt) and standard drug metformin (50 mg / kg ; b.wt) were administered to the diabetic rats.
Blood glucose was estimated on the 11th day and the level of MDA, SOD and CAT was estimated in the liver tissue homogenate after the 15 days of experimental period.
MEMD showed significant inhibition of alpha amylase activity and the IC50 was found to be 48 lg / ml.
Oral administration of MEMD significantly reduced blood glucose level (P < 0.05), diminished the MDA level and refurbished depleted antioxidant enzymes and Insulin level to normalcy.
These findings revealed that M.
dioica seeds possess antihyperglycemic, antioxidant and anti lipid peroxidative activity and thus mitigate STZ-induced oxidative damage.
American Psychological Association (APA)
Rao, P. Sailaja& Mohan, G. Krishna. 2017. In vitro alpha-amylase inhibition and in vivo antioxidant potential of Momordica dioica seeds in streptozotocin-induced oxidative stress in diabetic rats. Saudi Journal of Biological Sciences،Vol. 24, no. 6, pp.1262-1267.
https://search.emarefa.net/detail/BIM-776454
Modern Language Association (MLA)
Rao, P. Sailaja& Mohan, G. Krishna. In vitro alpha-amylase inhibition and in vivo antioxidant potential of Momordica dioica seeds in streptozotocin-induced oxidative stress in diabetic rats. Saudi Journal of Biological Sciences Vol. 24, no. 6 (Sep. 2017), pp.1262-1267.
https://search.emarefa.net/detail/BIM-776454
American Medical Association (AMA)
Rao, P. Sailaja& Mohan, G. Krishna. In vitro alpha-amylase inhibition and in vivo antioxidant potential of Momordica dioica seeds in streptozotocin-induced oxidative stress in diabetic rats. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 6, pp.1262-1267.
https://search.emarefa.net/detail/BIM-776454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1266-1267
Record ID
BIM-776454