Effects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome
Joint Authors
Yonggang, Huang
Xiaosheng, Lu
Zhaoxia, Huang
Yilu, Chen
Jiqiang, Lv
Huina, Zhang
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 2 (28 Feb. 2017), pp.241-245, 5 p.
Publisher
Publication Date
2017-02-28
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Objective: Effects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome were analyzed.
Methods: 90 patients with polycystic ovarian syndrome treated from January 2015 to March 2016 were randomly and evenly divided into control group and observation group.
Patients in the control group were only treated with clomiphene.
On the basis of the treatment in control group, human chorionic gonadotropin was added in the treatment of observation group.
The changes of E2, FSH, LH, PRL levels were compared between two groups before and after the treatment.
Clinical curative effects of patients in the two groups was evaluated.
Adverse reactions during treatment in two groups were observed and recorded.
The incidence of adverse reactions was calculated.
Results: Serum E2, FSH, LH and PRL levels in the two groups decreased significantly after treatment compared with that before treatment.
The difference is statistical significant (P <0.05).
After the treatment, E2, FSH, LH and PRL levels in the observation group were lower than that in the control group and the difference is statistical significant (P< 0.05).
Total effective rate was 64.44% in the control group and 93.33% in the observation group.
There were statistically significant difference in clinical curative effects in the two groups (P <0.05).
Different degrees of adverse reactions were found in both groups during treatment, such as nausea, vomiting, anorexia, liver dysfunction.
There were 2 cases of nausea, 2 cases of vomiting, 3 cases of anorexia and 1 case of liver dysfunction from the 45 patients in control group.
The total incidence of adverse reactions was 17.78% (8/45).
There were 1 case of nausea, 1 case of vomiting, 1 case of anorexia and no liver dysfunction from the 45 patients in observation group.
The total incidence of adverse reactions was
American Psychological Association (APA)
Yonggang, Huang& Xiaosheng, Lu& Zhaoxia, Huang& Yilu, Chen& Jiqiang, Lv& Huina, Zhang. 2017. Effects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome. Saudi Journal of Biological Sciences،Vol. 24, no. 2, pp.241-245.
https://search.emarefa.net/detail/BIM-776462
Modern Language Association (MLA)
Yonggang, Huang…[et al.]. Effects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome. Saudi Journal of Biological Sciences Vol. 24, no. 2 (Feb. 2017), pp.241-245.
https://search.emarefa.net/detail/BIM-776462
American Medical Association (AMA)
Yonggang, Huang& Xiaosheng, Lu& Zhaoxia, Huang& Yilu, Chen& Jiqiang, Lv& Huina, Zhang. Effects of human chorionic gonadotropin combined with clomiphene on serum E2, FSH, LH and PRL levels in patients with polycystic ovarian syndrome. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 2, pp.241-245.
https://search.emarefa.net/detail/BIM-776462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 244-245
Record ID
BIM-776462