Neuroprotective effects of quercetin in diabetic rat retina
Joint Authors
Ula, Muhammad S.
Shams, Shakib
Ahmad, Muna Mustafa
al-Rajai, Salim S.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 6 (30 Sep. 2017), pp.1186-1194, 9 p.
Publisher
Publication Date
2017-09-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Abstract EN
Diabetic retinopathy (DR) is a severe complication of diabetes and the leading cause of blindness among working adults worldwide.
DR is being widely recognized as a neurodegenerative disease of the retina, since, retinal neurons are damaged soon after diabetes onset.
Diabetes-induced oxidative stress is considered as central factor that dysregulates neurotrophic factors and activates apoptosis, thereby damages neurons in the diabetic retina.
Flavonoids being a powerful antioxidant have been considered to protect neurons in diabetic retina.
The purpose of this study was to analyze the beneficial effects of flavonoid, quercetin to protect neurons in the diabetic rat retina.
We quantitated the expression levels of BDNF, NGF, TrkB, synaptophysin, Akt, Bcl-2, cytochrome c and caspase-3 using Western blotting techniques in the diabetic retina with and without quercetin treatments and compared with non-diabetic rats.
In addition, we employed ELISA techniques to determine the level of BDNF.
Caspase-3 activity and the level of glutathione were analyzed by biochemical methods.
Our results indicate that quercetin treatment to diabetic rats caused a significant increase in the level of neurotrophic factors and inhibited the level of cytochrome c and caspase-3 activity in the diabetic retina.
Furthermore, the level of an anti-apoptotic protein Bcl-2 was augmented in quercetin treated diabetic retina.
Thus, quercetin, may protect the neuronal damage in diabetic retina by ameliorating the levels of neurotrophic factors and also by inhibiting the apoptosis of neurons.
Therefore, this study suggests that quercetin can be a suitable therapeutic agent to prevent neurodegeneration in diabetic retinopathy.
American Psychological Association (APA)
Ula, Muhammad S.& Ahmad, Muna Mustafa& Shams, Shakib& al-Rajai, Salim S.. 2017. Neuroprotective effects of quercetin in diabetic rat retina. Saudi Journal of Biological Sciences،Vol. 24, no. 6, pp.1186-1194.
https://search.emarefa.net/detail/BIM-776499
Modern Language Association (MLA)
Ula, Muhammad S.…[et al.]. Neuroprotective effects of quercetin in diabetic rat retina. Saudi Journal of Biological Sciences Vol. 24, no. 6 (Sep. 2017), pp.1186-1194.
https://search.emarefa.net/detail/BIM-776499
American Medical Association (AMA)
Ula, Muhammad S.& Ahmad, Muna Mustafa& Shams, Shakib& al-Rajai, Salim S.. Neuroprotective effects of quercetin in diabetic rat retina. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 6, pp.1186-1194.
https://search.emarefa.net/detail/BIM-776499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1192-1194
Record ID
BIM-776499