Antimicrobial susceptibility patterns of gram-negative bacteria causing urinary tract infections

Abstract EN

Microbial drug resistance is a major problem in the treatment of urinary tract infections worldwide.

A hospital-based descriptive retrospective study was implemented to investigate the occurrence of Gram-negative bacteria causing urinary tract infections and to assess their antimicrobial sensitivity patterns in Nasser Medical Complex, Gaza-Strip.

The study included all urine samples collected from adults for culture investigation during the period from January 2014 to December 2014.

Positive culture was defined as growth of a single bacterial species with colony count of ≥ 100,000 cfu/ml.

A total of 331 Gram-negative isolates were studied, females constituted the source of 198 isolates (59.8%), whereas 133 isolates (40.2%) were from males.

The common Gram-negative isolates were E.

coli (56.9%), Klebsiella sp.

(19.1%) and Enterobacter sp.

(10.9%).

Thirteen commonly locally used antibiotics were implemented in this study.

It is found that 83.7% of the isolates showed sensitivity to amikacin, 72.7% to ciprofloxacin and 69.5% to ceftazidim.

The lowest sensitivity was shown to amoxicillin (10.3%), cotrimethoprim (31.1%) and cepahlexin (38.1%).

Results of this study may suggest ciprofloxacin as an empirical treatment in our region for urinary tract infections until susceptibility reports are issued