Effect of gold nanoparticles on mice splenomegaly induced by schistosomiasis mansoni
Joint Authors
Khalil, Muna F. K.
Dkhil, Muhammad A.
Bayyumi, Amirah A.
Dhiyab, Marwah S. M.
al-Quraishy, Salih
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 6 (30 Sep. 2017), pp.1418-1423, 6 p.
Publisher
Publication Date
2017-09-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Schistosomiasis is still one of the main parasitic diseases that affect human health in tropical regions.
Whilst praziquantel (PZQ) is the main classic antischistosomal drug, the need for new drugs is still a must due to the low effectiveness of the drug on the schistosome young worms, and the evolving of PZQ resistant strains.
Nanotechnology is one of the most important recent and current methods used to treat human diseases including parasitic ones.
Therefore, the present study aimed to examine the curative role of gold nanoparticles (GNPs) on splenic tissue of mice infected with Schistosoma mansoni Sambon, 1907.
High-resolution transmission electron microscopy was used for characterization of nanoparticles (NP).
GNPs of 1 mg/kg mice body weight were inoculated into mice infected with S.
mansoni.
The parasite caused deteriorations in histological architecture of the spleen tissue, and splenomegaly.
Additionally, the parasite induced a significant reduction in splenic tissue glutathione levels; however, the concentrations of nitric oxide and malondialdehyde were significantly increased.
Treatment of mice with GNPs reduced the extent of histological impairment and oxidative stress in spleen tissue.
Therefore, our results demonstrate the protective role of GNPs against splenic damage in mice infected with S.
mansoni.
American Psychological Association (APA)
Dkhil, Muhammad A.& Khalil, Muna F. K.& Dhiyab, Marwah S. M.& Bayyumi, Amirah A.& al-Quraishy, Salih. 2017. Effect of gold nanoparticles on mice splenomegaly induced by schistosomiasis mansoni. Saudi Journal of Biological Sciences،Vol. 24, no. 6, pp.1418-1423.
https://search.emarefa.net/detail/BIM-776634
Modern Language Association (MLA)
Dkhil, Muhammad A.…[et al.]. Effect of gold nanoparticles on mice splenomegaly induced by schistosomiasis mansoni. Saudi Journal of Biological Sciences Vol. 24, no. 6 (Sep. 2017), pp.1418-1423.
https://search.emarefa.net/detail/BIM-776634
American Medical Association (AMA)
Dkhil, Muhammad A.& Khalil, Muna F. K.& Dhiyab, Marwah S. M.& Bayyumi, Amirah A.& al-Quraishy, Salih. Effect of gold nanoparticles on mice splenomegaly induced by schistosomiasis mansoni. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 6, pp.1418-1423.
https://search.emarefa.net/detail/BIM-776634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1422-1423
Record ID
BIM-776634