Epidemiology of human leukocyte antigens among Omani population

Abstract EN

Oman is located on the Southeastern coast of the Arabian Peninsula, and its population has high levels of consanguinity.

Human leukocytic antigen (HLA) typing analysis in human population holds unexploited potential for elucidating the genetic causes of human disease and possibly leads to personalized medicine.

This is a retrospective, descriptive study evaluating HLA frequencies of Omani individuals who underwent workup for kidney transplantation at the Royal Hospital (RH) from 2005 to 2016.

Data on 870 subjects were collected from the Oman kidney transplant registry at RH as well from electronic medical record system.

The mean age (standard deviation) years for the cohort were 33.2 (13.0).

Males constituted 56.3 % (490) while females constituted 43.7 % (380).

Seven HLA-A alleles accounted for more than 70 % of the total alleles.

Of which, HLA-A2 contributed the highest frequency (24 %), followed by HLA A11 (9.4 % ), and A32 (8.1 %).

Ten alleles accounted for 70 % of HLA-B alleles.

Of which, HLA-B51 was the most common (18.9 %), followed by HLA-B 35 (13.6 %), and HLA-B8 (7.9 %).

Seven HLA-DRB1 alleles accounted for more than 70 % of the total HLA DRB1 alleles, of which HLADRB1* 16 contributed the highest frequency (29.56 %).

This was followed by HLA-DRB1*03 (14.57 % ) and HLA-DRB1*11 (9.48 %).

While three alleles accounted for more than 75 % of the total HLA DQB1alleles.

Of which, HLA-DQB1*05 contributed the highest frequency (37.56 % ).

This was followed by allele HLA-DQB1 * 02 (26.48 %) and HLA-DQB1*03 (17.18 %).

This study showed considerable heterogeneity in both HLA Class I and Class II antigens, which reflects admixture of our population with rest of old world countries.

Despite the high levels of consanguinity