Nephrocalcinosis among children at King Hussein Medical Center : causes and outcome
Joint Authors
al-Bdirat, Jwahir T.
Mardini, Riham I.
Farrah, Mahdi K.
al-Bdirat, Amir T.
Salaita, Ghazi M.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 5 (31 Oct. 2017), pp.1064-1068, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-10-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Nephrocalcinosis (NC) is defined as deposition of calcium crystals in the renal parenchyma and tubules.
This is a retrospective review of all the data of 63 children presented to Pediatric Nephrology Clinic at King Hussein Medical Center (KHMC) over a 15-year period with bilateral NC.
We determine their causes, clinical presentation and evaluate their growth and renal function during their follow-up.
Thirty-five (55.5 %) cases were males and 28 (44.5 %) were females.
The median (range) age at presentation was four (2–192) months.
The most common leading cause to NC was hereditary tubulopathy in 48 % followed by hyperoxaluria in 35 %.
The cause of NC remained unknown in 3 % and Vitamin D excess accounts for 5 % of the cases.
The most presenting symptom was a failure to thrive (68 %) and the second most common symptom was abdominal pain and recurrent urinary tract infection was found in 40 %, polyuria and polydipsia were found in 32 % of cases, and 16 % of cases were diagnosed incidentally.
At a median follow-up of 38 (14–200) months, estimated glomerular filtration rate had decreased from 84.0 (42–110) mL / min per 1.73 m2 body surface area to 68.2 (10–110) mL / min / 1.73 m2 body surface (P = 0.001).
This study illustrated the need for a national registry of rare renal diseases to help understand the causes of these conditions in our populations and provide support to affected patients and their families.
American Psychological Association (APA)
al-Bdirat, Jwahir T.& Mardini, Riham I.& Salaita, Ghazi M.& al-Bdirat, Amir T.& Farrah, Mahdi K.. 2017. Nephrocalcinosis among children at King Hussein Medical Center : causes and outcome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 5, pp.1064-1068.
https://search.emarefa.net/detail/BIM-776894
Modern Language Association (MLA)
al-Bdirat, Jwahir T.…[et al.]. Nephrocalcinosis among children at King Hussein Medical Center : causes and outcome. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 5 (Sep. / Oct. 2017), pp.1064-1068.
https://search.emarefa.net/detail/BIM-776894
American Medical Association (AMA)
al-Bdirat, Jwahir T.& Mardini, Riham I.& Salaita, Ghazi M.& al-Bdirat, Amir T.& Farrah, Mahdi K.. Nephrocalcinosis among children at King Hussein Medical Center : causes and outcome. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 5, pp.1064-1068.
https://search.emarefa.net/detail/BIM-776894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1068
Record ID
BIM-776894