Phytochemicals boost anti-inflammatory effect against gamma radiation : activities of ginger and coriander extracts

Abstract EN

Phytochemicals are known to modulate immune function, and possess antitumor and antimicrobial properties.

The present study is conducted to evaluate the cytotoxic effect of ginger and coriander extracts against tumor cells (MTT) , anti-fungel and antioxidant activities of Ginger rhizome (Zingiber officinale) and Coriander (Coriandrum sativum)seed were evaluated.

Essential oil of both plants showed 100% inhibition against Alternaria Alternata pathogen.

The antioxidant activity showed the highest activities for ginger (methanol extract), whereas the lowest activity was for Coriander (water extract).

To study the antioxidant and radio-protective effect of Ginger and Coriander, Swiss albino mice were exposed to shot dose 4Gy γ radiation after 14 days oral administration of ginger (100mg/Kg b.wt) and coriander extracts (600 mg/kg b.wt).

After irradiation, anti –inflammatory mediators and phospholipase A2 were examined.

In conclusion, Ginger and Coriander showed significant antioxidant and radio-protective effects