The B fibrinogen gene G-455A polymorphism in Asian subjects with coronary heart disease : a meta analysis
Author
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 18, Issue 1 (31 Jan. 2017), pp.19-28, 10 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background : There are many studies about the association of b fibrinogen gene G-455A polymorphism and the risk of coronary heart disease (CHD).
However, the results of these studies are inconsistent.
Objective : This study aimed to investigate the association of b fibrinogen gene G-455A polymorphism with the risk of CHD using meta analysis.
This study was limited to the Asian population.
Methods : Published studies from PubMed, Embase, and CNKI databases (up to December 20th, 2015) were searched for eligible publications.
The following information was extracted from each study : (1) name of first author; (2) year of publication; (3) country of origin; (4) sample size of cases and controls, and (5) size of each allele.
The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between b fibrinogen gene G-455A polymorphism and the risk of CHD were assessed using random or fixed effect model.
A comprehensive meta analysis (CMA) 2.0 was used to analyze the data.
Results : Nineteen studies (4011 cases/3673 controls) regarding the association of b fibrinogen gene G-455A polymorphism and the risk of CHD were included in this meta analysis.
The results indicated that b fibrinogen gene G-455A polymorphism was associated with increased (A vs.
G: OR 95% CI= 1.42 [1.19–1.70], p<0.001; AA vs.
GG +GA: OR 95% CI= 1.60 [1.13–2.26], p= 0.008; GA vs.
GG + AA: OR 95% CI = 1.30 [1.07–1.58], p= 0.008) and decreased the risk of CHD (G vs.
A: OR 95% CI= 0.70 [0.59–0.84], p <0.001; GG vs.
GA +AA: OR 95% CI= 0.68 [0.55–0.84], p< 0.001).
Conclusions : In the Asian population, the b fibrinogen gene G-455A polymorphism was associated with the risk of CHD.
2016 Ain Shams University.
Production
American Psychological Association (APA)
Fajar, Jonny Karunia. 2017. The B fibrinogen gene G-455A polymorphism in Asian subjects with coronary heart disease : a meta analysis. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 1, pp.19-28.
https://search.emarefa.net/detail/BIM-777829
Modern Language Association (MLA)
Fajar, Jonny Karunia. The B fibrinogen gene G-455A polymorphism in Asian subjects with coronary heart disease : a meta analysis. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 1 (Jan. 2017), pp.19-28.
https://search.emarefa.net/detail/BIM-777829
American Medical Association (AMA)
Fajar, Jonny Karunia. The B fibrinogen gene G-455A polymorphism in Asian subjects with coronary heart disease : a meta analysis. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 1, pp.19-28.
https://search.emarefa.net/detail/BIM-777829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 27-28
Record ID
BIM-777829