Effect of some neurotransmitters on pituitary in bull-camel

Abstract EN

The present in vitro study is an attempt for profound exploration of the influence of some inhibitory (GABA and taurine) and excitatory neurotransmitters (glutamic acid and L-Argnine) on pituitary gland gonadotropic hormones in camels.

For this purpose, neurotransmitters were added individually to pituitary cells in vitro.

Results of current study revealed that addition of GABA alone has a potent inhibitory influence on gonadotropins release; an action which was dosedependent.

In addition, exaggerated high dose of GABA added to culture resulting in depression of GnRH activity.

Inhibitory neurotransmitter taurine preserved gonadotropins release within their normal values and maintained the stimulatory potentials of GnRH.

On the other side, nitric oxide had a stimulatory action at small dose rates and a depressive effect at higher dose rates.

Glutamic acid as the major endogenous excitatory neurotransmitter had a potent dose-dependent excitatory effect upon FSH and LH as well as GnRH stimulatory influence