Anti-inflammatory activity of losartan in experimentally-induced respiratory disease in rat model

Abstract EN

This study was carried out to evaluate the anti-inflammatory effect of losartan in 18 female rats which were divided into 3 groups.

Respiratory disease were experimentally induced by the intraperitoneal injection and spray inhalation of ovalbumin (OVA) in first and second group while third group left as negative control group.

First group were treated with losartan orally at dose rate of 5 mg/kg body weight, on the other hand second group considered as positive control group.

ELISA test were used to estimate the concentration of TNF-α, IL-4 in BALF and total IgE in serum samples.

Total WBC, neutrophil, eosinophil and lymphocyte were counted in bronchoaleveolar lavage (BAL).

First and second rat groups show signs of pulmonary disease.

Losartan treated group showed significant (p<0.05) decrease in concentration of TNF-α (152.483 pg/ml), IL-4 (39.733 pg/ml) in BALF and total serum IgE (56.006 pg/ml) in comparison with positive control group.

A significant decrease (p<0.05) were also detected for total WBC (101.33 x103), neutrophil (8.83 x103), eosinophil (15.50 x103 ) and lymphocytes (15 x103 ) in BALF of losartan treated rat group in compare to positive control group.