Antifungal activities of alcoholic and aqeuous extracts of punica granatum against some non-dermatophytic fungi

Abstract EN

A clinical and mycological study of superficial mycosis was conducted on 23 cases (7 males and 16 females) , and collected from patients (5-50) years old.

Direct microscopy by KOH (potassium hydroxide) mount and culture was undertaken to isolate the fungal pathogen in each case.

Non-dermatophyte molds were isolated from 18 cases (78.26%) and 21 isolates were identified from these cases ; 10 isolates Candida albicans (47.61%), 5 isolates Rhizopus stolonifer (23.8%), 2 isolates Penicillium sp.

and 2 isolates Aspergillus nidulans (9.5%) respectively, 1 isolate Alternaria alternata and1 isolate Fusarium sp.

(4.7%) respectively .

Alcoholic & aqueous extracts of the punica granatum (Pomegranate) peels were prepared.

The anti-fungal activity of the extracts was evaluated on isolated fungi by means of the agar-well diffusion assay.

The Minimum inhibitory concentrations were 10-300 mg/ml against isolated fungi.

Their was little difference between the activities of alcoholic extract & aqueous extract.

These results suggest the Pomegranate Peels extract which contains active constituents as a promising anti-fungal agent.