Study of the correlation between brain natriuretic peptide and each of malondialdehyde, ceruloplasmin and transferrin in patients with heart failure (HF)‎ in Thi-Qar governorate

Abstract EN

Objective: Heart failure is a chronic condition where the heart is unable to provide the different organs with adequate circulation of blood due to abnormality in the heart and changes in the hemodynamic, kidney, nerve and hormone system.

The present study is designed to determine the levels of Brain natriuretic peptide (BNP), Malondialdehyde (MDA), Ceruloplasmin (Cp) and transferring (Tf) in patients with systolic Heart failure (HF) with Hypertension and healthy individuals.

Subjects: Serum Brain natriuretic peptide, malondialdehyde, ceruloplasmin and transferrin were measured in 68 patients heart failure and 68 supposedhealthy subjects .

Results:The levels of serum Brain natriuretic peptide, malondialdehyde and ceruloplasmin were revealed significant increase in patients with heart failure as compared to control group whereas the levels transferrin showed a significant decrease in heart failure patients in comparison to control subjects(P ≤0.05).This study was also revealed the correlation between the concentrations of the measured parameters and BNP.

Conclusion:This study revealed significant increase BNP in patients with (HF) and Serum BNP may have a significant diagnostic role in heart failure.Lipid peroxidation and oxidative stress is more prominent in patients with (HF) comparison to healthy individuals , and there is a disorder in antioxidant system in patient with heart failure .according to the levels of ceruloplasmin and transferring