Evaluation the protective effect of catharanthusroseus extract on induced peptic ulcer in male rabbits

Abstract EN

The goal of this study is to evaluate the role of Catharanthusroseus alcoholic extraction for treatment of induced peptic ulcer in male rabbits in which there was thirty male , the animals was divided in five groups normal control given only distal water, active control given 500 mg/kg acetyl salsylic acid orally, standard group received single dose 20mg/kg IP of omeprazole follow by 500mg/kg acetyl salsylic acid, the fourth and fifth group received 20, 30mg/kg subsequently ofC.

roseusextract orally by stomach tube one hour before acetyl salsylic acid 500mg/kg orally, macroscopically significant protective effect of C.roseus extract show in dose of 30mg/kg about 61.97%, microscopically in both 20,30mg/kg the sign of healing process were detected which was approximately same as that appear in the standard group, measuring serum level of pro-inflammatory cytokines (IL-4and IL-8),showed there was significant reduction in there level at same level in both doses ,so as conclusion the alcoholic extraction of C.roseus had an antiulcerognic effect with significant reduction in the both IL-4 and IL-8.