Assessments of C-reactive protein and its correlation with total antioxidant capacity in woman with poly cystic ovary syndrome

Abstract EN

Objective: Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy.

The pathogenesis of PCOS is associated with both heredity and environment.

PCOS has adverse impacts on female endocrine, reproduction, and metabolism.

PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss.

PCOS has additional metabolic derangements, such as insulin resistance, impaired glucose tolerance, and dyslipidemia.

The risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased as well.

C-reactive protein (CRP) is a member of a group of acute phase of protein which increase their concentrations during certain inflammation disorders and used as a biomarker of inflammation in the body.

The aim of the presented work is to determine the level of CRP and then to evaluate its correlation with total antioxidant capacity in sera of women with PCOS.

Materials and Methods: This study was carried out on 120 women within the reproductive age (18-45 years old).

Sixty patient of them were attended from gynecological and obstetric hospital in Karbala province, and they all diagnosed by their physicians as polycystic ovary syndrome, and they compared with another sixty healthy control women with regular-menstrual cycle , fertile with age range (18-45 years) from November 2015 till October 2016.

Total cholesterol, triglyceride, HDL-C, LDL-C, VLDL-C, total antioxidant capacity and CRP were determined in each sample by various techniques.

Then various correlations were measured by SPSS system.

Results: The PCOS patients and the control group were obese and non-obese (30 patients of each).

The mean age of obese PCOS was (27.26 ± 0.83) whereas for obese control was (28.1 ± 0.713) with a high significance p < 0.01 in HDL-C, T-AOC and CRP.

The comparison between non-obese PCOS, means of age (25.5 ± 0.87) with non-obese control, means of age (27.3 ± 0.68) a high significance p < 0.01 in HDL-C and T-AOC was obtained.

While there is no significant correlation between T-AOC and CRP in obese and non-obese groups, respectively.

Conclusions: From the presented results, C-reactive protein levels as one of cardiac biomarkers was elevated in PCOS patients which revealed that PCOS is associated with dyslipidemia and altered oxidative status.

Obesity appeared to be a major factor associated with elevated cardiac markers.