Biological activities of plant extracts from ficus elastica and selaginella vogelli : an an timalarial, antitrypanosomal and cytotoxity evaluation
Joint Authors
Teinkela, Jean Emmanuel Mbosso
Noundou, Xavier Siwe
Nguemfo, Edwige Laure
Meyer, Franck
Wintjens, Rene
Isaacs, Michelle
Mpondo, Albert Emmanuel Mpondo
Hoppe, Heinrich C.
Krause, Rui Werner Maçedo
Azebaze, Anatole Guy Blaise
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 1 (31 Jan. 2018), pp.117-122, 6 p.
Publisher
Publication Date
2018-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated.
Wood of Ficus elastica Roxb.
ex Hornem.
aerial roots (Moraceae) and Selaginella vogelii Spring (Selaginellaceae) leaves were collected from two different sites in Cameroon.
In vitro cell-growth inhibition activities were assessed on methanol extract of plant materials against Plasmodium falciparum strain 3D7 and Trypanosoma brucei brucei, as well as against HeLa human cervical carcinoma cells.
Criteria for activity were an IC50 value < 10 lg/mL.
The extract of S.
vogelii did not significantly reduce the viability of P.
falciparum at a concentration of 25 lg/mL but dramatically affected the trypanosome growth with an IC50 of 2.4 lg/mL.
In contrast, at the same concentration, the extract of F.
elastica exhibited plasmodiacidal activity (IC50 value of 9.5 lg/mL) and trypanocidal (IC50 value of 0.9 lg/mL) activity.
Both extracts presented low cytotoxic effects on HeLa cancer cell line.
These results indicate that the selected medicinal plants could be further investigated for identifying compounds that may be responsible for the observed activities and that may represent new leads inparasitical drug discovery.
American Psychological Association (APA)
Teinkela, Jean Emmanuel Mbosso& Noundou, Xavier Siwe& Nguemfo, Edwige Laure& Meyer, Franck& Wintjens, Rene& Isaacs, Michelle…[et al.]. 2018. Biological activities of plant extracts from ficus elastica and selaginella vogelli : an an timalarial, antitrypanosomal and cytotoxity evaluation. Saudi Journal of Biological Sciences،Vol. 25, no. 1, pp.117-122.
https://search.emarefa.net/detail/BIM-780406
Modern Language Association (MLA)
Teinkela, Jean Emmanuel Mbosso…[et al.]. Biological activities of plant extracts from ficus elastica and selaginella vogelli : an an timalarial, antitrypanosomal and cytotoxity evaluation. Saudi Journal of Biological Sciences Vol. 25, no. 1 (Jan. 2018), pp.117-122.
https://search.emarefa.net/detail/BIM-780406
American Medical Association (AMA)
Teinkela, Jean Emmanuel Mbosso& Noundou, Xavier Siwe& Nguemfo, Edwige Laure& Meyer, Franck& Wintjens, Rene& Isaacs, Michelle…[et al.]. Biological activities of plant extracts from ficus elastica and selaginella vogelli : an an timalarial, antitrypanosomal and cytotoxity evaluation. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 1, pp.117-122.
https://search.emarefa.net/detail/BIM-780406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 121-122
Record ID
BIM-780406