Potentiation of antibiotic activity by Passiflora cincinnata Mast. front of strains Staphylococcus aureus and Escherichia coli
Joint Authors
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Figueredo, Fernando G.
Felipe, Cıcero F. B.
Kerntopf, Marta R.
Costa, Jose Galberto M. da
Martins, Anita Oliveira Brito Pereira Bezerra
Siebra, David C.
Albuquerque, Rosimeire S.
Lemos, Izabel Cristina Santiago
Delmondes, Gyllyandeson A.
Tintino, Saulo R.
Oliveira, Larissa R.
Siebra, Ana Luiza A.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 1 (31 Jan. 2018), pp.37-43, 7 p.
Publisher
Publication Date
2018-01-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The development of new drugs from plants is an interesting alternative approach to overcoming microbial resistance.
Passiflora cincinnata shows resistance to diseases and pests and a higher concentration of chemical components that may be useful in the pharmaceutical industry.
We investigated the potential antimicrobial and antibiotic-modifying activity of hydroalcoholic extracts of leaves, stems, bark, pulp and seeds of P.
cincinnata.
The extracts were prepared by homogenization of material in 50% ethanol.
Minimum inhibitory concentration (MIC) was determined by the broth dilution method, and the bacterial strains tested were Staphylococcus aureus and Escherichia coli.
Antibiotic-modifying activity was evaluated against the strains S.
aureus 03 and E.
coli 08, using a subinhibitory concentration of extract.
The antibiotics tested were: amikacin, gentamicin, ampicillin, potassium benzylpenicillin and oxacillin.
The extracts did not show antimicrobial activity of clinical relevance, where the MIC was equal to or greater than 1024 lg/mL.
S.
aureus showed 13 events, while E.
coli showed only 4 events.
Among these events, 14 involved synergistic activity, potentiating the effect of the antibiotics, and only 3 events demonstrated antagonistic activity toward ampicillin.
Hydroalcoholic extracts are potential antimicrobial agents when combined with conventional drugs little utilized in in vivo treatment.
American Psychological Association (APA)
Siebra, Ana Luiza A.& Oliveira, Larissa R.& Martins, Anita Oliveira Brito Pereira Bezerra& Siebra, David C.& Albuquerque, Rosimeire S.& Lemos, Izabel Cristina Santiago…[et al.]. 2018. Potentiation of antibiotic activity by Passiflora cincinnata Mast. front of strains Staphylococcus aureus and Escherichia coli. Saudi Journal of Biological Sciences،Vol. 25, no. 1, pp.37-43.
https://search.emarefa.net/detail/BIM-780407
Modern Language Association (MLA)
Siebra, Ana Luiza A.…[et al.]. Potentiation of antibiotic activity by Passiflora cincinnata Mast. front of strains Staphylococcus aureus and Escherichia coli. Saudi Journal of Biological Sciences Vol. 25, no. 1 (Jan. 2018), pp.37-43.
https://search.emarefa.net/detail/BIM-780407
American Medical Association (AMA)
Siebra, Ana Luiza A.& Oliveira, Larissa R.& Martins, Anita Oliveira Brito Pereira Bezerra& Siebra, David C.& Albuquerque, Rosimeire S.& Lemos, Izabel Cristina Santiago…[et al.]. Potentiation of antibiotic activity by Passiflora cincinnata Mast. front of strains Staphylococcus aureus and Escherichia coli. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 1, pp.37-43.
https://search.emarefa.net/detail/BIM-780407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 42-43
Record ID
BIM-780407