Synthesis, characterization and biological activity of some new O-arylation of thienopyridone-3-carboxylates

Other Title(s)

تحضير و تشخيص و دراسة الفاعلية الحيوية لبعض مركبات O-أريلاتيون ثينو بيريدون-3-كاربوكسيلات الجديدة

Dissertant

al-Tani, Muhammad Rafi Ayid

Thesis advisor

al-Tarawinah, Salah A.

Comitee Members

al-Abisat, Hamdan S.
al-Tawil, Samir A.
al-Shahatit, Sulhi F.

University

Mutah University

Faculty

Faculty of Science

Department

Department of Chemistry

University Country

Jordan

Degree

Master

Degree Date

2017

English Abstract

A new series of substituted ethyl 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4- oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate 97a-f have been prepared utilizing ethyl 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[ 2,3-b]pyridine-5-carboxylate 95 and phenol 96a or Salicylaldehyde derivatives 96b-f.

By replacing of the 2-chloroine atom by phenol 96a and Salicylaldehyde derivatives 96b-f anion to produce the respective ethyl 7- cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine- 5-carboxylate 97a-f.

The new compounds are supported by using different spectroscopic techniques such as ( IR, 1H-NMR, 13C-NMR 2D (COSY HMQR and HMBC), elemental analysis (C H N) and ESI-HRMS).

Then evaluate the bioactivity of the new compounds

Main Subjects

Physics

No. of Pages

75

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-780420