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Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia
Joint Authors
Kim, Su Kang
Kim, Young Ock
GyuKo, Il
Park, Hae Jeong
Cho, Kyu Bong
Kwon, Oh Young
Park, Kyeong Hun
Park, Chun Geon
Ahn, Young-Sup
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 1 (31 Jan. 2018), pp.65-70, 6 p.
Publisher
Publication Date
2018-01-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The prostatic hyperplasia in benign prostatic hyperplasia (BPH) leads to obstructive micturition symptoms.
Previous studies showed that pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preopticnucleus (MPA) regions in the brain have been known to regulate the urinary bladder function.
The present study shows the influences of Panax ginseng on nerve growth factor (NGF) expressions in PMC, vlPAG, and MPA regions in the brain.
Wistar rats were used for the present study.
The rats split into four groups; 4 groups (n =6) in control group, BPH-induced group, BPH-induced and P.
ginseng-treated group, and BPH-induced and finasteride-treated group.
BPH in rats was induced by testosterone and the animals were evaluated for NGF expression in PMC, vlPAG, and MPA regions in the brain.
The NGF expression was identified using immunohistochemistry (IHC).
The NGF expression by IHC showed spots with dark brown color.
In our results, NGF expressions in PMC, vlPAG, and MPA regions in the brainstem of the BPH-induced group showed increase than the control animal.
These increased NGF expressions in three regions were decreased using treatment with P.
ginseng (200 mg/kg).
These results suggest that P.
ginseng has therapeutic effects on the symptoms of BPH and is associated with the regulation of NGF expression in the brain.
In conclusion, the administration of P.
ginseng helps nerve growth factor activation.
American Psychological Association (APA)
Kim, Su Kang& GyuKo, Il& Park, Hae Jeong& Cho, Kyu Bong& Kwon, Oh Young& Park, Kyeong Hun…[et al.]. 2018. Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia. Saudi Journal of Biological Sciences،Vol. 25, no. 1, pp.65-70.
https://search.emarefa.net/detail/BIM-780475
Modern Language Association (MLA)
Kim, Su Kang…[et al.]. Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia. Saudi Journal of Biological Sciences Vol. 25, no. 1 (Jan. 2018), pp.65-70.
https://search.emarefa.net/detail/BIM-780475
American Medical Association (AMA)
Kim, Su Kang& GyuKo, Il& Park, Hae Jeong& Cho, Kyu Bong& Kwon, Oh Young& Park, Kyeong Hun…[et al.]. Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 1, pp.65-70.
https://search.emarefa.net/detail/BIM-780475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 69-70
Record ID
BIM-780475