Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia

Joint Authors

Kim, Su Kang
Kim, Young Ock
GyuKo, Il
Park, Hae Jeong
Cho, Kyu Bong
Kwon, Oh Young
Park, Kyeong Hun
Park, Chun Geon
Ahn, Young-Sup

Source

Saudi Journal of Biological Sciences

Issue

Vol. 25, Issue 1 (31 Jan. 2018), pp.65-70, 6 p.

Publisher

Saudi Biological Society

Publication Date

2018-01-31

Country of Publication

Saudi Arabia

No. of Pages

6

Main Subjects

Natural & Life Sciences (Multidisciplinary)

Abstract EN

The prostatic hyperplasia in benign prostatic hyperplasia (BPH) leads to obstructive micturition symptoms.

Previous studies showed that pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial preopticnucleus (MPA) regions in the brain have been known to regulate the urinary bladder function.

The present study shows the influences of Panax ginseng on nerve growth factor (NGF) expressions in PMC, vlPAG, and MPA regions in the brain.

Wistar rats were used for the present study.

The rats split into four groups; 4 groups (n =6) in control group, BPH-induced group, BPH-induced and P.

ginseng-treated group, and BPH-induced and finasteride-treated group.

BPH in rats was induced by testosterone and the animals were evaluated for NGF expression in PMC, vlPAG, and MPA regions in the brain.

The NGF expression was identified using immunohistochemistry (IHC).

The NGF expression by IHC showed spots with dark brown color.

In our results, NGF expressions in PMC, vlPAG, and MPA regions in the brainstem of the BPH-induced group showed increase than the control animal.

These increased NGF expressions in three regions were decreased using treatment with P.

ginseng (200 mg/kg).

These results suggest that P.

ginseng has therapeutic effects on the symptoms of BPH and is associated with the regulation of NGF expression in the brain.

In conclusion, the administration of P.

ginseng helps nerve growth factor activation.

American Psychological Association (APA)

Kim, Su Kang& GyuKo, Il& Park, Hae Jeong& Cho, Kyu Bong& Kwon, Oh Young& Park, Kyeong Hun…[et al.]. 2018. Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia. Saudi Journal of Biological Sciences،Vol. 25, no. 1, pp.65-70.
https://search.emarefa.net/detail/BIM-780475

Modern Language Association (MLA)

Kim, Su Kang…[et al.]. Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia. Saudi Journal of Biological Sciences Vol. 25, no. 1 (Jan. 2018), pp.65-70.
https://search.emarefa.net/detail/BIM-780475

American Medical Association (AMA)

Kim, Su Kang& GyuKo, Il& Park, Hae Jeong& Cho, Kyu Bong& Kwon, Oh Young& Park, Kyeong Hun…[et al.]. Effects of Panax ginseng on the nerve growth factor expression in testosterone induced benign prostatic hyperplasia. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 1, pp.65-70.
https://search.emarefa.net/detail/BIM-780475

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 69-70

Record ID

BIM-780475