Effect of ethanolic extract of Salvia Triloba on serum biochemical parameters and skin inflammation of adult rat offspring after prenatal cigarette smoke exposure

Other Title(s)

تأثير المستخلص الايثانولي لنبات الميرامية على الخصائص الكيميائية الحيوية للدم و الالتهابات الجلدية في أطفال الجردان بعد تعرض الأمهات إلى دخان السجائر

Dissertant

al-Rawashidah, Rami Bassam

Thesis advisor

al-Shakhanbah, Jumah Muti Muhammad

Comitee Members

Khulayfat, Khalid Muhammad
al-Mustafa, Ahmad Husayn Husayn
al-Harub, Amir Munawwir

University

Mutah University

Faculty

Faculty of Science

Department

Department of Biological Sciences

University Country

Jordan

Degree

Master

Degree Date

2017

English Abstract

This study was intended to evaluate the changes in biochemical parameters and the anti-inflammatory activity in carrageenan induced paw edema in adult rat offspring after prenatal oral administration ethanolic extracted of Salvia triloba plant and/or cigarettes smoke exposure.

White albino rats were divided into four groups; control group(1), prenatally ethanolic extract treated group(2), prenatally cigarette smoke exposed group(3) and prenatally ethanolic extract treated group exposed to cigarette smoke (4).

Mothers have been treated orally 375 mg/kg body weight of ethanolic extract of Salvia triloba and/or cigarette smoke exposure at (3time/2 cigarette/day) during the period of pregnancy.

For anti-inflammatory activity test, all groups were injected (intradermal) with 0.1 ml of 1% lambda carrageenan, and the degree of paw edema was assessed.

In adult male rat offspring; glucose level was significantly increased in group 4.However, urea, cholesterol, LDL, iron level and cholesterol /HDL Ratio were significantly decreased in groups 2,3 and 4, creatinine level significantly decreased in group 2.

HDL, alkaline phosphatase, total protein, albumin, globulin and calcium level were significantly decreased in groups 2 and 4.

In adult female rat offspring; albumin level was significantly increased in group 2, globulin level was significantly increased in group 4, however glucose level and cholesterol /HDL Ratio were significantly decreased in groups 2 and 3, AST level was significant decreased in groups 2,3 and 4.

alkaline phosphatase, amylase level were significantly decreased in group 4.

total bilirubin significant decreased on group 2, as compared to control group.

On the other hand the inhibition of carrageenan induced rat paw edema was significantly decreased in groups 2,3 and 4 as compared to control paw (saline).

It is concluded that prenatal ethanolic extract of salvia triloba treated and/or cigarette smoke exposure were induced significant changes in some serum biochemical parameters of the adult rat offspring.

In addition prenatal ethanolic extract of salvia triloba treated and/or cigarette smoke exposure showed significant anti-inflammatory activity in adult rat offspring rat skin.

Main Subjects

Botany

No. of Pages

55

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-780516