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Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study
Joint Authors
Zhou, Mingguang
Zhou, Guojin
Hu, SunHong
Zhang, Lei
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 2 (28 Feb. 2018), pp.267-272, 6 p.
Publisher
Publication Date
2018-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Nasopharyngeal carcinoma (NPC) at present is considered to be one of the fatal diseases detected commonly in the people belonging to southeast Asia and southern China.
According to the WHO reports among the detected cases of NPC worldwide, 80 % are from China.
The present study investigates the effect of tanshinone IIA on the migration and invasion potential of HNE1NPC cells and studied the detailed mechanism involved.
Effect of the tanshinone IIA on viability of the HNE-1NPC cells was analyzed by MTS assay.
Cell matrigel invasion and wound-healing motility assays, respectively were used for the analysis of invasion and migration potential of HNE-1 cells.
Tanshinone IIA inhibited the viability of HNE-1 cells in a dose dependent manner.
Migration and invasion potential of the tanshinone IIA treated cells was reduced significantly (P < 0.05) compared to the control cells after 48 h.
Analysis of the proteins involved in migration and invasion revealed a significant decrease in the expression of matrix metalloproteinase (MMP)-2 and MMP-9 on treatment with tanshinone IIA.
It also inhibited the p65 and p50 expression in the nuclear fractions of HNE-1 cells after 48 h.
Thus, tanshinone IIA inhibits migration and invasion potential of the HNE-1NPC cells through reduction in the expression of matrix metalloproteinases.
Therefore, tanshinone IIA can be used for the treatment of NPC.
American Psychological Association (APA)
Zhou, Mingguang& Zhou, Guojin& Hu, SunHong& Zhang, Lei. 2018. Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study. Saudi Journal of Biological Sciences،Vol. 25, no. 2, pp.267-272.
https://search.emarefa.net/detail/BIM-780517
Modern Language Association (MLA)
Zhou, Mingguang…[et al.]. Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study. Saudi Journal of Biological Sciences Vol. 25, no. 2 (Feb. 2018), pp.267-272.
https://search.emarefa.net/detail/BIM-780517
American Medical Association (AMA)
Zhou, Mingguang& Zhou, Guojin& Hu, SunHong& Zhang, Lei. Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 2, pp.267-272.
https://search.emarefa.net/detail/BIM-780517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 271-272
Record ID
BIM-780517