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Effect of Zhen Qi Fu Zheng granules on the bone marrow depression model induced by Zidorf
Joint Authors
Miao, Mingsan
Cao, Lihua
Chen, Gangling
Bai, Ming
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 2 (28 Feb. 2018), pp.220-225, 6 p.
Publisher
Publication Date
2018-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Zidorf is a commonly used drug for the treatment of AIDS, the most common side effects of AZT was bone marrow depression.
Therefore, we investigated the effects of Zhen Qi Fu Zheng (AQFZ) granules on the model of bone marrow depression induced by AZT.
We showed that the high, medium and low doses of AQFZ granules could increase the number of WBC in the mice model induced by AZT, and the difference was significant (P < 0.01) compared with the model group.
Each dose of AQFZ granules can increase the thymus cortex thickness, the number of thymus lymphocytes, spleen nodule size, the number of lymphocytes in the spleen (P < 0.01).
The medium dose of AQFZ granules can also significantly improve the number of BMC in the bone marrow depression model (P < 0.01).
As well as, the low dose of AQFZ granules can clearly increase the number of nucleated cells in a bone marrow (P < 0.05) and IL-2blood serum.
So, AQFZ granules can improve and regulate the hemogram, bone marrow and immune level of bone marrow depression model induced by AZT.
American Psychological Association (APA)
Miao, Mingsan& Cao, Lihua& Bai, Ming& Chen, Gangling. 2018. Effect of Zhen Qi Fu Zheng granules on the bone marrow depression model induced by Zidorf. Saudi Journal of Biological Sciences،Vol. 25, no. 2, pp.220-225.
https://search.emarefa.net/detail/BIM-780574
Modern Language Association (MLA)
Miao, Mingsan…[et al.]. Effect of Zhen Qi Fu Zheng granules on the bone marrow depression model induced by Zidorf. Saudi Journal of Biological Sciences Vol. 25, no. 2 (Feb. 2018), pp.220-225.
https://search.emarefa.net/detail/BIM-780574
American Medical Association (AMA)
Miao, Mingsan& Cao, Lihua& Bai, Ming& Chen, Gangling. Effect of Zhen Qi Fu Zheng granules on the bone marrow depression model induced by Zidorf. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 2, pp.220-225.
https://search.emarefa.net/detail/BIM-780574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 224-225
Record ID
BIM-780574