Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats
Joint Authors
Sun, Yanru
Han, Mingfeng
Shen, Zhenhuang
Huang, Haibo
Miao, Xiaoqing
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 2 (28 Feb. 2018), pp.213-219, 7 p.
Publisher
Publication Date
2018-02-28
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Ventricular remodeling is associated with many heart diseases, and ventricular remodeling induced by hypertension can be fatal independent of hypertension.
In this study, we prepared a novel apitherapy formulation, designated Bao-Yuan-Ling (BYL), which contained propolis, royal jelly, and bee venom, to treat spontaneous hypertensive rats (SHRs).
We then evaluated the pharmacology of BYL and the potential mechanisms through which BYL affects hypertension and ventricular remodeling.
We found that BYL treatment could reduce blood pressure in SHRs.
Thereafter, we found that BYL treatment reduced serum levels of angiotensin II, endothelin 1, and transforming growth factor-β and improved the myocardial structure.
Moreover, the results of quantitative real-time polymerase chain reaction indicated that BYL treatment could upregulate the mRNA expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ.
Thus, we could conclude that BYL had hypotensive and cardioprotective effects in SHRs, potentially through improvement of myocardial energy metabolism.
American Psychological Association (APA)
Sun, Yanru& Han, Mingfeng& Shen, Zhenhuang& Huang, Haibo& Miao, Xiaoqing. 2018. Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats. Saudi Journal of Biological Sciences،Vol. 25, no. 2, pp.213-219.
https://search.emarefa.net/detail/BIM-780578
Modern Language Association (MLA)
Sun, Yanru…[et al.]. Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats. Saudi Journal of Biological Sciences Vol. 25, no. 2 (Feb. 2018), pp.213-219.
https://search.emarefa.net/detail/BIM-780578
American Medical Association (AMA)
Sun, Yanru& Han, Mingfeng& Shen, Zhenhuang& Huang, Haibo& Miao, Xiaoqing. Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 2, pp.213-219.
https://search.emarefa.net/detail/BIM-780578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 218-219
Record ID
BIM-780578