Involvement of erbB4 and tumor marker genes in renal carcinoma regulatory network
Joint Authors
Wang, Xiaofu
Hao, Bin
Xu, Changbao
Liu, Changwei
Chu, Xiaohan
Zhao, Yongli
Zhang, Shengwei
Wang, Pengsen
Wang, Youzhi
Zhao, Xinghua
Lv, Yuan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 8 (31 Dec. 2017), pp.1787-1791, 5 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Background : renal carcinoma is a common urologic tumor, and there is no ideal tumor marker for clinical diagnosis except for imaging diagnosis.
This study aims to screen the serum tumor markers closely related with the benign and malignant of renal carcinoma out and chart out the regulatory network that involves renal carcinoma-related genes.
Methods : based on 96 pathologically diagnosed renal cancer patients, factors strongly linked to renal carcinoma character were selected using Fisher discriminant analysis.
The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases were utilized to manipulate function annotation of erbB4 and the selected genes and pathway analysis.
Results: Four essential tumor markers CYFRA21-1, CA125, VHL and HIF-1b were successfully screened out.
Using GO and KEGG databases, the regulatory network of renal cancer cell escaping apoptosis was charted out on the basis of erbB4 signaling pathway.
Conclusion : serum tumor marker genes play a certain part in the genesis and development of renal carcinoma.
We preliminarily illustrated the molecular mechanism of these markers to predict tumor, laying a foundation for further exploration in renal carcinoma.
American Psychological Association (APA)
Wang, Xiaofu& Hao, Bin& Xu, Changbao& Zhao, Xinghua& Liu, Changwei& Chu, Xiaohan…[et al.]. 2017. Involvement of erbB4 and tumor marker genes in renal carcinoma regulatory network. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1787-1791.
https://search.emarefa.net/detail/BIM-780601
Modern Language Association (MLA)
Wang, Xiaofu…[et al.]. Involvement of erbB4 and tumor marker genes in renal carcinoma regulatory network. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1787-1791.
https://search.emarefa.net/detail/BIM-780601
American Medical Association (AMA)
Wang, Xiaofu& Hao, Bin& Xu, Changbao& Zhao, Xinghua& Liu, Changwei& Chu, Xiaohan…[et al.]. Involvement of erbB4 and tumor marker genes in renal carcinoma regulatory network. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1787-1791.
https://search.emarefa.net/detail/BIM-780601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1790-1791
Record ID
BIM-780601