Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro
Joint Authors
Li, Minjie
Ke, Sunkui
Duan, Hongbing
Wu, Chaohui
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 8 (31 Dec. 2017), pp.1859-1865, 7 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Non-small cell lung cancer (NSCLC) is a major type of lung cancer, with the highest mortality rate in all cancers.
For all stages of NSCLC, the five-year survival is less than fifteen percent.
Epithelial-mesenchymal transition (EMT) is a significant process in tumor occurrence and development, in which microRNAs may play an important role.
In many cancers, microRNA-15’s family member can act as suppressors or oncogenes of tumors ; however, the relation between these microRNAs and EMT in lung cancer remains unclear.
According to our study, miR-15a expression decreased in tumor tissues compared with than that in adjacent tissue samples.
Knocking down miR-15a expression in NSCLC cells inhibited apoptosis andfacilitated cell proliferation and invasion, and.
Moreover, down-regulating miR-15a decreased the expression of an EMT-associated protein, E-cadherin, while increased those of vimentin, N-cadherin, and slug.
American Psychological Association (APA)
Li, Minjie& Ke, Sunkui& Duan, Hongbing& Wu, Chaohui. 2017. Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1859-1865.
https://search.emarefa.net/detail/BIM-780613
Modern Language Association (MLA)
Li, Minjie…[et al.]. Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1859-1865.
https://search.emarefa.net/detail/BIM-780613
American Medical Association (AMA)
Li, Minjie& Ke, Sunkui& Duan, Hongbing& Wu, Chaohui. Knocking down MiR-15a expression promotes the occurrence and development and induces the EMT of NSCLC cells in vitro. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1859-1865.
https://search.emarefa.net/detail/BIM-780613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1865
Record ID
BIM-780613