Bio-functionalized gold nanoparticles : benign effect in Sprague-Dawley rats by intravenous administration
Joint Authors
Parveen, Asra
Malashetty, Vijaykumar B.
Mantripragada, Bhagavanraju
Yalagatti, Manjunath S.
Abbaraju, Venkataraman
Deshpande, Raghunandan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 8 (31 Dec. 2017), pp.1925-1932, 8 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Gold nanoparticles offer a great promise in clinical research.
Despite various applications of the metal nanoparticles it is challenging to implement in vivo in clinical applications.
This aspect is deprived of understanding the biological mechanisms that occurs in the cells.
In this report we have evaluated application of AuNP on the safety profile at different doses (100, 200, and 500 lg/kg Bwt/day) on intravenous administration in rats regularly for 28 days.
The study was performed based on the OECD test guideline 407.
No clinical signs and mortalities were observed in any groups of rat treated with AuNP.
No evidence of toxicity was observed in any of the diverse studies performed which is noteworthy.
The study includes survival, behavior, animal weight, organ morphology, blood biochemistry and tissue histology.
The results indicate that tissue accumulation pattern of gold nanoparticles depends on the surface, size and doses of the nanoparticle.
The accumulation of the particles does not produce subacute physiological damage.
American Psychological Association (APA)
Parveen, Asra& Malashetty, Vijaykumar B.& Mantripragada, Bhagavanraju& Yalagatti, Manjunath S.& Abbaraju, Venkataraman& Deshpande, Raghunandan. 2017. Bio-functionalized gold nanoparticles : benign effect in Sprague-Dawley rats by intravenous administration. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1925-1932.
https://search.emarefa.net/detail/BIM-780621
Modern Language Association (MLA)
Parveen, Asra…[et al.]. Bio-functionalized gold nanoparticles : benign effect in Sprague-Dawley rats by intravenous administration. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1925-1932.
https://search.emarefa.net/detail/BIM-780621
American Medical Association (AMA)
Parveen, Asra& Malashetty, Vijaykumar B.& Mantripragada, Bhagavanraju& Yalagatti, Manjunath S.& Abbaraju, Venkataraman& Deshpande, Raghunandan. Bio-functionalized gold nanoparticles : benign effect in Sprague-Dawley rats by intravenous administration. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1925-1932.
https://search.emarefa.net/detail/BIM-780621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1931-1932
Record ID
BIM-780621