In-vitro antioxidative, antiinflammatory properties of Aurea helianthus leaf extract a Korean traditional medicinal plant
Joint Authors
Kim, Young Ock
Park, Chun Geon
Kim, Hak Jae
Varghese, Rakesh
Lee, Ji Yeon
Sung, Gi Ho
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 8 (31 Dec. 2017), pp.1943-1947, 5 p.
Publisher
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The leaf of Aurea helianthus (A.
helianthus Jinhuakui) is popularly used in China traditional medicine, however, scientific evidence on its antioxidant properties rarely studied.
In this study, biological activities of A.
helianthus leave’s 80% ethanol extract (AHL) were investigated.
The measured total polyphenol and flavonoid content of AHL was 184.24 ± 5.01 mg GAE / g and 102.53 ± 0.98 mg NAR/g.
AHL showed the highest a, a-diphenyl-b-picrylhydrazyl (DPPH) and 2,20-azino-bis-3-ethylbenzo-thiazoline-6-sulfonic acid (ABTS) radical scavenging activities of 98.30 ± 0.18 % at 1000 mg / mL.
DPPH and ABTS radical scavenging activities significantly increased in a AHL concentration-dependent manner.
AHL treatment significantly suppressed the generation of pro-inflammatory mediators, including nitric oxide (NO), in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
AHL demonstrated strong anti-inflammatory activity that reduced NO production in LPS-stimulated RAW 264.7 cells.
To test the potential protective effect of AHL, the antioxidant capacity, on the cell growth, viability of a human hepatoma cell (HepG2) and Raw 264.7 cell were investigated.
AHL also enhanced cytotoxicity on the proliferation of HepG2 cells and was capable of inhibiting 56 % against LPS at 400 mg/mL.
The results of this study the potential of AHL as an excellent antioxidant substance for inhibiting inflammatory mediators.
Therefore, AHL may be used as a therapeutic approach to various inflammatory diseases
American Psychological Association (APA)
Kim, Hak Jae& Park, Chun Geon& Varghese, Rakesh& Lee, Ji Yeon& Kim, Young Ock& Sung, Gi Ho. 2017. In-vitro antioxidative, antiinflammatory properties of Aurea helianthus leaf extract a Korean traditional medicinal plant. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1943-1947.
https://search.emarefa.net/detail/BIM-780624
Modern Language Association (MLA)
Kim, Hak Jae…[et al.]. In-vitro antioxidative, antiinflammatory properties of Aurea helianthus leaf extract a Korean traditional medicinal plant. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1943-1947.
https://search.emarefa.net/detail/BIM-780624
American Medical Association (AMA)
Kim, Hak Jae& Park, Chun Geon& Varghese, Rakesh& Lee, Ji Yeon& Kim, Young Ock& Sung, Gi Ho. In-vitro antioxidative, antiinflammatory properties of Aurea helianthus leaf extract a Korean traditional medicinal plant. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1943-1947.
https://search.emarefa.net/detail/BIM-780624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1947
Record ID
BIM-780624