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The tumor suppressor NDRG2 disrupts the oncogenicity of the cytoplasmic PRMT5 in atl leukemia
Other Title(s)
ال ان دي آر جي الثاني المثبط للأورام يحدث خللا في قدرة ال بي آر ام تي الخامس المتواجد في السيتوبلازم على أحداث التورم في مرض الابيضاض التائي الخلايا
Joint Authors
Ismail, Muhammad Nur al-Din
Abu Shanab, Ubayd Mahmud Muhammad
Morishita, Kazuhiro
Muhammad, Muhammad Salah Abd Allah
Nassar, Ahmad Yasin Ahmad
Source
Assiut Veterinary Medical Journal
Issue
Vol. 63, Issue 153 (30 Apr. 2017), pp.145-156, 12 p.
Publisher
Assiut University Faculty of Veterinary Medicine
Publication Date
2017-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Adult T-cell leukemia (ATL) is an oncogenic disease derived from the HTLV-1-infected T cells and there is no effective therapy known yet.
We previously reported that down-regulation of N-myc downstream-regulated gene-2 (NDRG2) expression by DNA Methylation and genetic deletion presents one of the most common alterations in adult T-cell leukemia (ATL) and other various kinds of cancers.
A stress-induced NDRG2 suppresses important signaling pathways (PI3K and NF-κB) through the de-phosphorylation of PTEN and NIK as a PP2A recruiter.
In this manuscript, we identified protein arginine methyltransferase 5 (PRMT5) as a NDRG2/PP2A binding partner.
A NDRG2/PP2A complex down-regulated arginine methyltransferase activity of PRMT5 through de-phosphorylation of the serine and threonine residues and changing its co-localization to the nucleus of ATL cell lines increasing the histone arginine methylation; however, PRMT5 was highly phosphorylated and localized in cytoplasm in NDRG2-deficient ATL.
American Psychological Association (APA)
Abu Shanab, Ubayd Mahmud Muhammad& Morishita, Kazuhiro& Nassar, Ahmad Yasin Ahmad& Ismail, Muhammad Nur al-Din& Muhammad, Muhammad Salah Abd Allah. 2017. The tumor suppressor NDRG2 disrupts the oncogenicity of the cytoplasmic PRMT5 in atl leukemia. Assiut Veterinary Medical Journal،Vol. 63, no. 153, pp.145-156.
https://search.emarefa.net/detail/BIM-780907
Modern Language Association (MLA)
Muhammad, Muhammad Salah Abd Allah…[et al.]. The tumor suppressor NDRG2 disrupts the oncogenicity of the cytoplasmic PRMT5 in atl leukemia. Assiut Veterinary Medical Journal Vol. 63, no. 153 (Apr. 2017), pp.145-156.
https://search.emarefa.net/detail/BIM-780907
American Medical Association (AMA)
Abu Shanab, Ubayd Mahmud Muhammad& Morishita, Kazuhiro& Nassar, Ahmad Yasin Ahmad& Ismail, Muhammad Nur al-Din& Muhammad, Muhammad Salah Abd Allah. The tumor suppressor NDRG2 disrupts the oncogenicity of the cytoplasmic PRMT5 in atl leukemia. Assiut Veterinary Medical Journal. 2017. Vol. 63, no. 153, pp.145-156.
https://search.emarefa.net/detail/BIM-780907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 155-156
Record ID
BIM-780907