Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1, 3, 4-oxadiazole scaffolds
Joint Authors
Yang, Song
Zhou, Lei
Zhou, Jian
Wang, Pei Yi
Fang, He Shu
Shao, Wu Bin
Wua, Zhi Bing
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 7 (30 Nov. 2017), pp.852-860, 9 p.
Publisher
Publication Date
2017-11-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Herein, a series of pyridinium-tailored 5-trifluoromethylpyrazoles containing 1,3, 4-oxadiazole moieties were constructed through coupling key pharmaceutical fragments of pyridinium, pyrazole, and 1,3,4-oxadiazole scaffolds in single molecular architecture.
Antimicrobial results suggested that this kind of compounds exhibited significant activities against three types of pathogenic bacteria and six fungal strains in vitro.
The minimal EC50 values of designed compounds against Xanthomonas oryzae pv.
oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv.
citri could reach to 0.467, 1.04, and 0.600 lg/mL, respectively, through tuning and optimizing N-substituents, bridging atom, and alkyl length of the tailor.
Antifungal assays revealed that all title molecules possessed considerable activity against Botrytis cinerea with the minimal EC50 value up to 2.71 lg/mL; and compounds I-8, I-10, I-12, II-12, and IV-12 showed the strongest growth suppression toward Rhizoctonia solani with EC50 values ranging from 10.2 to 24.0 lg/mL.
Given the above results, this kind of compounds could serve as new lead compounds in the research of antimicrobial chemotherapy.
American Psychological Association (APA)
Zhou, Lei& Wang, Pei Yi& Zhou, Jian& Fang, He Shu& Shao, Wu Bin& Wua, Zhi Bing…[et al.]. 2017. Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1, 3, 4-oxadiazole scaffolds. Journal of Saudi Chemical Society،Vol. 21, no. 7, pp.852-860.
https://search.emarefa.net/detail/BIM-781837
Modern Language Association (MLA)
Zhou, Lei…[et al.]. Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1, 3, 4-oxadiazole scaffolds. Journal of Saudi Chemical Society Vol. 21, no. 7 (Nov. 2017), pp.852-860.
https://search.emarefa.net/detail/BIM-781837
American Medical Association (AMA)
Zhou, Lei& Wang, Pei Yi& Zhou, Jian& Fang, He Shu& Shao, Wu Bin& Wua, Zhi Bing…[et al.]. Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1, 3, 4-oxadiazole scaffolds. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 7, pp.852-860.
https://search.emarefa.net/detail/BIM-781837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 859-860
Record ID
BIM-781837