Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1, 2, 3] triazole hybrids
Joint Authors
Thatipamula, Ranjith kumar
Narsimha, Sirassu
Battula, Kumaraswamy
Chary, V. Rajendra
Mamidala, Estari
Reddy, Nagavelli Vasudeva
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 7 (30 Nov. 2017), pp.795-802, 8 p.
Publisher
Publication Date
2017-11-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
A series of novel (isopropylidene) uridine-[1,2,3]triazole hybrids (3a–3n) were efficiently synthesized via the copper-catalyzed azide–alkyne cycloaddition (CuAAC) from N-propargyl 20,30- O-(isopropylidene) uridine with different aryl azides.
All the synthesized compounds were screened for their in vitro anticancer and antibacterial activities.
The anticancer activity results revealed that compounds 3d and 3f have registered equipotent activity against MCF-7 and 3n has shown excellent activity against HeLa in comparison with the standard drug Cisplatin.
Remaining compounds have shown moderate to good anticancer activity against MCF-7 and HeLa cell lines.
The antibacterial activity screening results revealed that, compounds 3b and 3n have shown excellent inhibition against Escherichia coli and Bacillus subtilis, 3d against Proteus vulgaris, 3k against Staphylococcus aureus and 3l against S.
aureus and B.
subtilis have shown equipotent activity in comparison with the standard drug Streptomycin
American Psychological Association (APA)
Thatipamula, Ranjith kumar& Narsimha, Sirassu& Battula, Kumaraswamy& Chary, V. Rajendra& Mamidala, Estari& Reddy, Nagavelli Vasudeva. 2017. Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1, 2, 3] triazole hybrids. Journal of Saudi Chemical Society،Vol. 21, no. 7, pp.795-802.
https://search.emarefa.net/detail/BIM-781841
Modern Language Association (MLA)
Thatipamula, Ranjith kumar…[et al.]. Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1, 2, 3] triazole hybrids. Journal of Saudi Chemical Society Vol. 21, no. 7 (Nov. 2017), pp.795-802.
https://search.emarefa.net/detail/BIM-781841
American Medical Association (AMA)
Thatipamula, Ranjith kumar& Narsimha, Sirassu& Battula, Kumaraswamy& Chary, V. Rajendra& Mamidala, Estari& Reddy, Nagavelli Vasudeva. Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1, 2, 3] triazole hybrids. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 7, pp.795-802.
https://search.emarefa.net/detail/BIM-781841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 801-802
Record ID
BIM-781841