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Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents
Joint Authors
Bikobo, Dominique Serge Ngono
Vodnar, Dan C.
Stana, Anca
Tiperciuc, Brındusa
Nastasa, Cristina
Douchet, Maxime
Oniga, Ovidiu
Source
Journal of Saudi Chemical Society
Issue
Vol. 21, Issue 7 (30 Nov. 2017), pp.861-868, 8 p.
Publisher
Publication Date
2017-11-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
A series of 10 new N-phenyl-4-(4-(thiazol-2-yl)-phenyl)-thiazol-2-amine derivatives (3a–j) and 4 new 5-(2-(phenylamino)-thiazol-4-yl)-benzamide ethers (30a–d) were synthesized from 4-(2- phenylamino)-thiazol-4-yl)-benzothioamide and 2-hydroxy-5-(2-(phenylamino)-thiazol-4-yl)-benza mide with several a-halo-ketones, by the Hantzsch reaction.
All compounds were characterized by elemental analysis and spectral data (MS, FT-IR and NMR).
The final 14 substances were screened for antimicrobial activity, against two Gram-positive, one Gram-negative bacterial strains, and two fungal strains.
Some of the synthesized molecules were more potent than the reference drugs, against the pathogenic strains used.
The antibacterial activity of compounds was more pronounced against the Gram-positive strains.
Compound 3e manifested the highest growth inhibitory effect against all pathogens tested (MIC of 31.25 lg/mL against the Gram-positive bacterial strains and 7.81 lg/mL against the Candida strains).
American Psychological Association (APA)
Bikobo, Dominique Serge Ngono& Vodnar, Dan C.& Stana, Anca& Tiperciuc, Brındusa& Nastasa, Cristina& Douchet, Maxime…[et al.]. 2017. Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents. Journal of Saudi Chemical Society،Vol. 21, no. 7, pp.861-868.
https://search.emarefa.net/detail/BIM-781848
Modern Language Association (MLA)
Bikobo, Dominique Serge Ngono…[et al.]. Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents. Journal of Saudi Chemical Society Vol. 21, no. 7 (Nov. 2017), pp.861-868.
https://search.emarefa.net/detail/BIM-781848
American Medical Association (AMA)
Bikobo, Dominique Serge Ngono& Vodnar, Dan C.& Stana, Anca& Tiperciuc, Brındusa& Nastasa, Cristina& Douchet, Maxime…[et al.]. Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents. Journal of Saudi Chemical Society. 2017. Vol. 21, no. 7, pp.861-868.
https://search.emarefa.net/detail/BIM-781848
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 868
Record ID
BIM-781848