Effect of vitamin E on reversibility of renal function following discontinuation of colistin in rats : histological and biochemical investigations
Joint Authors
Kallel, Rim
Ghlissi, Zahrah
Munif, Halah
Zaghal, Khalid
Boudawara, Tahiya
Sahnun, Zuhayr
Hakim, Ahmad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 1 (28 Feb. 2018), pp.10-18, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-02-28
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
This study was carried out to evaluate spontaneous renal regeneration after stopping colistin methanesulfonate (CMS), which induces tubular damage, and the curative effect of Vitamin E (vit E) in rats.
Animals were given the following: sterile saline (n = 6), 300,000 IU/kg/ day of CMS (n = 24), or 450,000 IU/kg/day of CMS (n = 24) for seven days.
Each CMS group was subdivided into four subgroups (n = 6) and sacrificed as follows: (i) 12 h after stopping CMS, (ii) two weeks after stopping CMS, (iii) two weeks after stopping treatment with vit E, and (iv) two weeks after stopping treatment with olive oil.
Subsequently, plasma creatinine (pCr), urine Nacetyl- b-D-glucosaminidase (NAG), renal tissue level of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione reductase (GSH), and renal histology were tested.
CMS-induced tubular damage increased the NAG and MDA levels and decreased the SOD and GSH activities.
After two weeks of stopping CMS, there was no significant renal recovery.
However, treatment with vit E improved tubular regeneration and reduced the biochemical impairments.
Two weeks might not be long enough for significant spontaneous renal regeneration.
Improvement of renal parameters by vit E could be explained by the reduction of oxidative stress damage
American Psychological Association (APA)
Ghlissi, Zahrah& Hakim, Ahmad& Munif, Halah& Kallel, Rim& Zaghal, Khalid& Boudawara, Tahiya…[et al.]. 2018. Effect of vitamin E on reversibility of renal function following discontinuation of colistin in rats : histological and biochemical investigations. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 1, pp.10-18.
https://search.emarefa.net/detail/BIM-781852
Modern Language Association (MLA)
Ghlissi, Zahrah…[et al.]. Effect of vitamin E on reversibility of renal function following discontinuation of colistin in rats : histological and biochemical investigations. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 1 (Jan. / Feb. 2018), pp.10-18.
https://search.emarefa.net/detail/BIM-781852
American Medical Association (AMA)
Ghlissi, Zahrah& Hakim, Ahmad& Munif, Halah& Kallel, Rim& Zaghal, Khalid& Boudawara, Tahiya…[et al.]. Effect of vitamin E on reversibility of renal function following discontinuation of colistin in rats : histological and biochemical investigations. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 1, pp.10-18.
https://search.emarefa.net/detail/BIM-781852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 17-18
Record ID
BIM-781852