Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats
Joint Authors
Shaykh, Altaf Husayn
Shaykh, Naib Rasul
al-Umar, Sulayman Yusuf
Muhammad, Altaf
Muhayya, Talal Abd al-Aziz
Kodidhela, Lakshmi Devi
Muhammad, Abd al-Karim
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 3 (31 Mar. 2018), pp.431-436, 6 p.
Publisher
Publication Date
2018-03-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The present study aimed to evaluate the effect of Terminalia pallida fruit ethanolic extract (TpFE) on lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase (PON) in isoproterenol (ISO)-induced myocardial infarcted rats.
PON is an excellent serum antioxidant enzyme which involves in the protection of low density lipoprotein cholesterol (LDL-C) from the process of oxidation for the prevention of cardiovascular diseases.
ISO caused a significant increase in the concentration of total cholesterol, triglycerides, LDL-C, very low density lipoprotein cholesterol and lipid peroxidation whereas significant decrease in the concentration of high density lipoprotein cholesterol.
ISO administration also significantly decreased the activities of lecithin cholesterol acyl transferase, PON and lipoprotein lipase whereas significantly increased the activity of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase.
Oral pretreatment of TpFE at doses 100, 300 and 500 mg / kg body weight (bw) and gallic acid (15 mg / kg bw) for 30 days challenged with concurrent injection of ISO (85 mg / kg bw) on 29th and 30th day significantly attenuated these alterations and restored the levels of lipids, lipoproteins and the activities of lipid metabolizing enzymes.
Also TpFE significantly elevated the serum antioxidant enzyme PON.
This is the first report revealed that pretreatment with TPFE ameliorated lipid metabolic marker enzymes and increased the antioxidant PON in ISO treated male albino Wistar rats.
American Psychological Association (APA)
Shaykh, Altaf Husayn& Shaykh, Naib Rasul& Muhammad, Abd al-Karim& al-Umar, Sulayman Yusuf& Muhammad, Altaf& Muhayya, Talal Abd al-Aziz…[et al.]. 2018. Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats. Saudi Journal of Biological Sciences،Vol. 25, no. 3, pp.431-436.
https://search.emarefa.net/detail/BIM-782040
Modern Language Association (MLA)
Shaykh, Altaf Husayn…[et al.]. Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats. Saudi Journal of Biological Sciences Vol. 25, no. 3 (Mar. 2018), pp.431-436.
https://search.emarefa.net/detail/BIM-782040
American Medical Association (AMA)
Shaykh, Altaf Husayn& Shaykh, Naib Rasul& Muhammad, Abd al-Karim& al-Umar, Sulayman Yusuf& Muhammad, Altaf& Muhayya, Talal Abd al-Aziz…[et al.]. Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 3, pp.431-436.
https://search.emarefa.net/detail/BIM-782040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 435-436
Record ID
BIM-782040