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Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera : Culicidae)
Joint Authors
Ibrahim, Khalid E.
al-Mikhlafi, Fahd A.
Abu Taha, Nail
Mashaly, Ashraf M. A.
Nasr, Fahd A.
Wadaan, Muhammad A.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 4 (31 May. 2017), pp.817-821, 5 p.
Publisher
Publication Date
2017-05-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Effects of methanol extracts of Xanthium strumarium on different cancer cell lines and on the mortality rates of Aedes caspius, Culex pipiens (Diptera: Culicidae) were investigated.
Among the cell lines tested, the Jurkat cell line was the most sensitive to the methanol extract and ethyl acetate fraction, with reported LC50 values of 50.18 and 48.73 lg/ml respectively.
Conversely, methanol extracts were not that toxic to the A549 cell line though the toxicity increased on further purification.
The percentage of growth inhibition was dose dependent for the methanol extract and ethyl acetate fraction.
The ethyl acetate fraction showed higher toxicity to all cell lines tested when compared to the methanol extract.
The results showed that methanol extracts of plant seeds caused 100% mortality of mosquito larvae at a concentration of 1000 lg/ml after 24 h of treatment.
The LC50 and LC90 values of X.
strumarium were found to be 531.07 and 905.95 lg/ml against Ae.
caspius and 502.32 and 867.63 lg/ml against Cx.
Pipiens, respectively.
From the investigations, it was concluded that the crude extract of X.
strumarium showed a weak potential for controlling the larval instars of Ae.
caspius and Cx.
pipiens.
However, on further purification the extract lost the larvicidal activity.
The ethyl acetate fraction showed higher toxicity to all cell lines tested when compared to the methanol extract.
The ethyl acetate fraction investigated in this study appears to have a weak larvicidal activity but a promising cytotoxic activity.
Future studies will include purification and investigation in further detail of the action of X.
strumarium on Cancer Cell Lines and mosquitoes.
American Psychological Association (APA)
al-Mikhlafi, Fahd A.& Abu Taha, Nail& Mashaly, Ashraf M. A.& Nasr, Fahd A.& Ibrahim, Khalid E.& Wadaan, Muhammad A.. 2017. Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera : Culicidae). Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.817-821.
https://search.emarefa.net/detail/BIM-782056
Modern Language Association (MLA)
al-Mikhlafi, Fahd A.…[et al.]. Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera : Culicidae). Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.817-821.
https://search.emarefa.net/detail/BIM-782056
American Medical Association (AMA)
al-Mikhlafi, Fahd A.& Abu Taha, Nail& Mashaly, Ashraf M. A.& Nasr, Fahd A.& Ibrahim, Khalid E.& Wadaan, Muhammad A.. Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera : Culicidae). Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.817-821.
https://search.emarefa.net/detail/BIM-782056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 820-821
Record ID
BIM-782056