Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes
Joint Authors
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 4 (31 May. 2017), pp.797-802, 6 p.
Publisher
Publication Date
2017-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The aim of this work was to prepare coenzyme Q10 (CoQ10) long-circulating liposomes, and establish the quality standard to determine the content and entrapment efficiency.
CoQ10 long-circulating liposomes were prepared by the film dispersion method, HPLC assay for the determination of CoQ10 was developed.
Free drugs and liposomes were separated using the protamine aggregation method and entrapment efficiency was determined.
The liposomes were homogeneous and the mean diameter was 166.0 nm, Zeta potential was 22.2 mV.
The content and entrapment efficiency of CoQ10 were 98.2 % and 93.2% for three batches of liposomes, respectively.
The lyophilized form of liposomes prepared by freeze-drying showed stable quality characteristics during storage.
The formulation and preparative method can be used to prepare CoQ10 long-circulating liposomes with high entrapment efficiency and high quality, the determination method of drug content and entrapment efficiency were effective and rapid and can be used for quality evaluation of liposomes.
American Psychological Association (APA)
Li, Huibin& Chen, Fang. 2017. Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.797-802.
https://search.emarefa.net/detail/BIM-782065
Modern Language Association (MLA)
Li, Huibin& Chen, Fang. Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.797-802.
https://search.emarefa.net/detail/BIM-782065
American Medical Association (AMA)
Li, Huibin& Chen, Fang. Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.797-802.
https://search.emarefa.net/detail/BIM-782065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 801-802
Record ID
BIM-782065