Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes

Joint Authors

Chen, Fang
Li, Huibin

Source

Saudi Journal of Biological Sciences

Issue

Vol. 24, Issue 4 (31 May. 2017), pp.797-802, 6 p.

Publisher

Saudi Biological Society

Publication Date

2017-05-31

Country of Publication

Saudi Arabia

No. of Pages

6

Main Subjects

Medicine

Topics

Abstract EN

The aim of this work was to prepare coenzyme Q10 (CoQ10) long-circulating liposomes, and establish the quality standard to determine the content and entrapment efficiency.

CoQ10 long-circulating liposomes were prepared by the film dispersion method, HPLC assay for the determination of CoQ10 was developed.

Free drugs and liposomes were separated using the protamine aggregation method and entrapment efficiency was determined.

The liposomes were homogeneous and the mean diameter was 166.0 nm, Zeta potential was 22.2 mV.

The content and entrapment efficiency of CoQ10 were 98.2 % and 93.2% for three batches of liposomes, respectively.

The lyophilized form of liposomes prepared by freeze-drying showed stable quality characteristics during storage.

The formulation and preparative method can be used to prepare CoQ10 long-circulating liposomes with high entrapment efficiency and high quality, the determination method of drug content and entrapment efficiency were effective and rapid and can be used for quality evaluation of liposomes.

American Psychological Association (APA)

Li, Huibin& Chen, Fang. 2017. Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.797-802.
https://search.emarefa.net/detail/BIM-782065

Modern Language Association (MLA)

Li, Huibin& Chen, Fang. Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.797-802.
https://search.emarefa.net/detail/BIM-782065

American Medical Association (AMA)

Li, Huibin& Chen, Fang. Preparation and quality evaluation of coenzyme Q10 long-circulating liposomes. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.797-802.
https://search.emarefa.net/detail/BIM-782065

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 801-802

Record ID

BIM-782065