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Synthesis, structural studies and antituberculosis evaluation of new hydrazone derivatives of quinoline and their Zn(II) complexes
Joint Authors
Mandewale, Mustapha C.
Thorat, Bapu
Jadhav, Ram
Nagarsekar, Aarti
Yamgar, Ramesh S.
Nivid, Y.
Source
Journal of Saudi Chemical Society
Issue
Vol. 22, Issue 2 (28 Feb. 2018), pp.218-228, 11 p.
Publisher
Publication Date
2018-02-28
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
The quinoline hydrazone ligands were synthesized through multi-step reactions.
The 2-hydroxy-3-formylquinoline derivatives (1a–1c) were prepared from acetanilide derivatives as starting materials using Vilsmeier–Haack reaction.
Then the condensation of 2-hydroxy-3-formylquinoline derivatives with hydrazide derivatives (2a–2c) yielded quinoline hydrazone ligands (3a–3i).
The synthesis of a new series of Zn(II) complexes carried out by refluxing with these quinoline hydrazone ligands (3a–3i) is reported.
The molecular structures of the ligands (3a–3i) and the Zn complexes were characterized by elemental analysis and spectral studies like FT-IR, 1 H and 13C NMR, MS, UV–Visible and orescence.
The preliminary results of antituberculosis study showed that most of the Zn(II) complexes 4a–4i demonstrated very good antituberculosis activity while the ligands 3a–3i showed moderate activity.
Among the tested compounds 4e and 4g were found to be most active with minimum inhibitory concentration (MIC) of 8.00 μM and 7.42 μM respectively against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294 which is comparable to ‘‘first and second line” drugs used to treat tuberculosis..
American Psychological Association (APA)
Mandewale, Mustapha C.& Thorat, Bapu& Nivid, Y.& Jadhav, Ram& Nagarsekar, Aarti& Yamgar, Ramesh S.. 2018. Synthesis, structural studies and antituberculosis evaluation of new hydrazone derivatives of quinoline and their Zn(II) complexes. Journal of Saudi Chemical Society،Vol. 22, no. 2, pp.218-228.
https://search.emarefa.net/detail/BIM-782066
Modern Language Association (MLA)
Mandewale, Mustapha C.…[et al.]. Synthesis, structural studies and antituberculosis evaluation of new hydrazone derivatives of quinoline and their Zn(II) complexes. Journal of Saudi Chemical Society Vol. 22, no. 2 (Feb. 2018), pp.218-228.
https://search.emarefa.net/detail/BIM-782066
American Medical Association (AMA)
Mandewale, Mustapha C.& Thorat, Bapu& Nivid, Y.& Jadhav, Ram& Nagarsekar, Aarti& Yamgar, Ramesh S.. Synthesis, structural studies and antituberculosis evaluation of new hydrazone derivatives of quinoline and their Zn(II) complexes. Journal of Saudi Chemical Society. 2018. Vol. 22, no. 2, pp.218-228.
https://search.emarefa.net/detail/BIM-782066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 227-228
Record ID
BIM-782066