Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent
Joint Authors
al-Farhan, A. H.
Rajakrishnan, R.
Benil, P. B.
Rakesh, V.
Khalaf, S.
Thomas, J.
Lekshmi, R. R.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 24, Issue 4 (31 May. 2017), pp.760-766, 7 p.
Publisher
Publication Date
2017-05-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research.
Plumbago zeylanica L.
is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities.
In the present study, the protective effect of hydroalcoholic extract of P.
zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice.
Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect.
The antioxidant effect of the drug is evident from its significant effect on Catalase, Glutathione peroxidase and lipid peroxidation activities.
American Psychological Association (APA)
Rajakrishnan, R.& Lekshmi, R. R.& Benil, P. B.& Thomas, J.& al-Farhan, A. H.& Rakesh, V.…[et al.]. 2017. Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.760-766.
https://search.emarefa.net/detail/BIM-782334
Modern Language Association (MLA)
Rajakrishnan, R.…[et al.]. Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.760-766.
https://search.emarefa.net/detail/BIM-782334
American Medical Association (AMA)
Rajakrishnan, R.& Lekshmi, R. R.& Benil, P. B.& Thomas, J.& al-Farhan, A. H.& Rakesh, V.…[et al.]. Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.760-766.
https://search.emarefa.net/detail/BIM-782334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 766
Record ID
BIM-782334