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Diffusion-weighted MRI and urinary Activin-A are potential predictors of severity in neonates with hypoxic ischemic encephalopathy
Joint Authors
Mahir, Shirin E.
al-Mazari, Abd al-Azim Muhammad
Isawi, Muhammad G.
Hijazi, Mahmud M.
Uqayli, Najwa I.
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 65, Issue 4 (30 Nov. 2017), pp.101-107, 7 p.
Publisher
Egyptian Pediatric Association
Publication Date
2017-11-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Early diagnosis and treatment are important to reduce neonatal morbidity and mortality occurring from hypoxic ischemic encephalopathy (HIE).
Objective : We aimed to correlate between urinary Activin-A and MRI (conventional and diffusionweighted) and the degree of HIE according to Sarnat and Sarnat staging.
Methods : Sixty full term neonates (37–42 weeks) selected from Minia University hospital for children from May 2014 to July 2016 were enrolled into the study.
We measured urinary Activin-A using enzyme immunoassay and MRI using MRI scanner (Philips Achieva) and correlations between urinary Activin-A and MRI with the degree of HIE were done.
Results : Neonates with HIE had higher levels of urinary Activin-A than controls (P < .001) and it was positively correlated with the clinical grading of HIE at cutoff value of 0.08 mg/l on day-1 after birth with a sensitivity 98.2% and specificity 97.1% for prediction of HIE.
DW-MRI detected HIE with a high sensitivity (85%) compared to the low sensitivity of conventional MRI (35%).
Apparent diffusion coefficient (ADC) value of 0.8 was the best sensitivity-specificity cutoff point for detecting severe ischemic injury.
DW-MRI imaging was positively correlated with the urinary Activin-A and both of them were positively correlated with the degree of HIE (P < .001).
Conclusions: DW-MRI imaging is correlated well with urinary Activin-A in full-term neonates with HIE and both of them are correlated with the degree of HIE.
Early determination of urinary Activin-A combined with DW-MRI imaging can early detect HIE and its degree of severity in full-term neonates with HIE.
American Psychological Association (APA)
Mahir, Shirin E.& al-Mazari, Abd al-Azim Muhammad& Isawi, Muhammad G.& Hijazi, Mahmud M.& Uqayli, Najwa I.. 2017. Diffusion-weighted MRI and urinary Activin-A are potential predictors of severity in neonates with hypoxic ischemic encephalopathy. Egyptian Pediatric Association Gazette،Vol. 65, no. 4, pp.101-107.
https://search.emarefa.net/detail/BIM-783190
Modern Language Association (MLA)
Mahir, Shirin E.…[et al.]. Diffusion-weighted MRI and urinary Activin-A are potential predictors of severity in neonates with hypoxic ischemic encephalopathy. Egyptian Pediatric Association Gazette Vol. 65, no. 4 (Nov. 2017), pp.101-107.
https://search.emarefa.net/detail/BIM-783190
American Medical Association (AMA)
Mahir, Shirin E.& al-Mazari, Abd al-Azim Muhammad& Isawi, Muhammad G.& Hijazi, Mahmud M.& Uqayli, Najwa I.. Diffusion-weighted MRI and urinary Activin-A are potential predictors of severity in neonates with hypoxic ischemic encephalopathy. Egyptian Pediatric Association Gazette. 2017. Vol. 65, no. 4, pp.101-107.
https://search.emarefa.net/detail/BIM-783190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 106-107
Record ID
BIM-783190