Breaking the ritual metabolic cycle in order to save acetyl CoA : a potential role for mitochondrial humanin in T2 bladder cancer aggressiveness
Joint Authors
Umar, Nisrin Nabil
Tash, Riham Fathi
Shukri, Yusuf
al-Said, Karim Umar
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 29, Issue 2 (30 Jun. 2017), pp.69-76, 8 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2017-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction: Cancer cells may exhibit outsourcing of their high energy need in order to avoid the intrinsic mitochondrial apoptosis.
Reduced mitochondrial respiration and accumulation of mitochondrial genome mutations are among metabolic transformations in this regard.
Mitochondrial humanin (MT-RNR2) is a small peptide with anti-apoptotic activities attributed to binding some pro-apoptotic proteins.
Aim of the work: The current study aims at investigating the expression of mitochondrial humanin in bladder tumor cells and the possible casting of humanin anti-apoptotic action through orchestrating some of the mitochondrial metabolic enzymes.
Material and methods: Here messenger RNA of humanin, succinate dehydrogenase, glutaminase, isocitrate dehydrogenase were compared in tissues from patients with T2 bladder carcinoma in comparison to tumor associated normal tissues from the same patients.
Levels of lactate and mitochondrial pyruvate carrier (MPC1) mRNA were determined to scrutinize the prevalence of aerobic glycolysis.
Results: The present study found that tumor cells had suppressed aerobic glycolysis, augmented mitochondrial respiration and interrupted tricarboxylic acid cycle, all of which were suggested to serve tumor aggressiveness.
MT-RNR2 was found closely related to the alterations in mitochondrial activity.
Conclusion: MT-RNR2 plays its anti-apoptotic role partly by avoiding deploying energy from complete oxidation of organic compounds to inorganic wastes.
Thus MT-RNR2 can potentially serve as a new biomarker in the diagnosis of bladder carcinoma especially that it is present in blood circulation
American Psychological Association (APA)
Umar, Nisrin Nabil& Tash, Riham Fathi& Shukri, Yusuf& al-Said, Karim Umar. 2017. Breaking the ritual metabolic cycle in order to save acetyl CoA : a potential role for mitochondrial humanin in T2 bladder cancer aggressiveness. Journal of the Egyptian National Cancer Institute،Vol. 29, no. 2, pp.69-76.
https://search.emarefa.net/detail/BIM-783267
Modern Language Association (MLA)
Umar, Nisrin Nabil…[et al.]. Breaking the ritual metabolic cycle in order to save acetyl CoA : a potential role for mitochondrial humanin in T2 bladder cancer aggressiveness. Journal of the Egyptian National Cancer Institute Vol. 29, no. 2 (Jun. 2017), pp.69-76.
https://search.emarefa.net/detail/BIM-783267
American Medical Association (AMA)
Umar, Nisrin Nabil& Tash, Riham Fathi& Shukri, Yusuf& al-Said, Karim Umar. Breaking the ritual metabolic cycle in order to save acetyl CoA : a potential role for mitochondrial humanin in T2 bladder cancer aggressiveness. Journal of the Egyptian National Cancer Institute. 2017. Vol. 29, no. 2, pp.69-76.
https://search.emarefa.net/detail/BIM-783267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 76
Record ID
BIM-783267