Maspin expression and subcellular localization in invasive ductal carcinoma of the breast : prognostic significance and relation to microvessel density
Joint Authors
Hilal, Dua S.
al-Jundi, Dina M.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 29, Issue 4 (31 Dec. 2017), pp.177-183, 7 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Maspin (Mammary serine protease inhibitor) is a tumor suppressor serine.
Its clinical significance and role in breast carcinoma are contradictory and inconclusive.
Researches demonstrated that the function of maspin differs according to its subcellular localization.
This study was conducted to investigate the expression of maspin in invasive ductal carcinoma (IDC) of the breast with special emphasis on its subcellular localization and to evaluate its prognostic role in relation to clinicopathological parameters and microvessel density (MVD) of the tumor.
The expression of maspin was evaluated immunohistochemically in 45 IDC cases.
The positive rate of maspin expression was 73.3%.
Maspin positivity was significantly related to higher tumor grade (p value = 0.041), nodal metastasis (p value = 0.044), perineural invasion (p value = 0.047), and high CD34+MVD (p value = 0.002).
Nuclear maspin was detected in 36.6% whereas cytoplasmic maspin was detected in 63.4% of maspin positive cases.
A significant inverse relationship was observed between nuclear maspin and high tumor grade (p value = 0.016), and nodal metastasis (p value = 0.047).
These results suggest that maspin expression has a prognostic role in breast cancer.
Maspin expression is related to increased angiogenesis.
Subcellular localization of maspin can strongly affect cancer prognosis.
Cytoplasmic maspin relates to poor prognostic parameters whereas nuclear maspin relates to good prognostic ones
American Psychological Association (APA)
Hilal, Dua S.& al-Jundi, Dina M.. 2017. Maspin expression and subcellular localization in invasive ductal carcinoma of the breast : prognostic significance and relation to microvessel density. Journal of the Egyptian National Cancer Institute،Vol. 29, no. 4, pp.177-183.
https://search.emarefa.net/detail/BIM-783273
Modern Language Association (MLA)
Hilal, Dua S.& al-Jundi, Dina M.. Maspin expression and subcellular localization in invasive ductal carcinoma of the breast : prognostic significance and relation to microvessel density. Journal of the Egyptian National Cancer Institute Vol. 29, no. 4 (Dec. 2017), pp.177-183.
https://search.emarefa.net/detail/BIM-783273
American Medical Association (AMA)
Hilal, Dua S.& al-Jundi, Dina M.. Maspin expression and subcellular localization in invasive ductal carcinoma of the breast : prognostic significance and relation to microvessel density. Journal of the Egyptian National Cancer Institute. 2017. Vol. 29, no. 4, pp.177-183.
https://search.emarefa.net/detail/BIM-783273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 182-183
Record ID
BIM-783273