Cardioprotective effects of vitamin B complex and Ethinyl estradiol in ovariectomized rats

Abstract EN

Background/aim Reduction of female sex hormones is associated with health disorders including cardiovascular diseases such as hypertension.

Supplementation with vitamin B complex can lower the incidence of these disorders.

The present study aimed to study the potential cardioprotective effects of vitamin B complex and ethinyl estradiol (EE) when administered alone or in combination to hormonal-deprived ovariectomized (OVX) rats.

Materials and methods Fifty female Wister rats were classified into five equal groups: the first group included normal rats, the second group was OVX (positive control), and the third to fifth groups were OVX rats that were treated by EE (0.03 mg/kg), vitamin B complex (9.036 mg/kg), and a combination of both treatments, respectively.

Treatment continued for eight successive weeks.

Blood pressure (BP), cystathionine γ-lyase (CSE), reduced glutathione (R-GSH), superoxide dismutase (SOD), catalase (CAT), and interleukinβ6 (IL-β6) were measured.

Results The OVX rats showed a significant increase in BP, reduction in CSE, R-GSH, SOD, and CAT, and increase in IL-β6 levels, whereas the treated OVX rats showed a significant decrease in BP, increase in CSE, R-GSH, SOD, and CAT, and reduction in IL-β6 levels.

Conclusion Vitamin B complex and EE exert cardioprotective effects in OVX rats.