Association assessment of Interleukine-10 gene polymorphism and its expression status with susceptibility to coronary artery disease in Iran
Joint Authors
Farazmandfar, Touraj
Shahbazi, Majid
Musavi, Sayyidah Zahrah
Salihi, Arif
Jurjani, Isa
Manzari, Rida Salihi
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 1 (31 Jan. 2018), pp.31-35, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background : The cytokines are potent inflammatory factors that regulate each stage of atherosclerosis leading to the disease development.
Interleukin-10 (IL-10) as an anti-inflammatory cytokine can develop atherosclerosis by inhibiting the synthesis of metalloproteinase.
Moreover, IL-10 promotes the plaque stability by preserving the extracellular matrix and fibrous cap.
Aim : We evaluated the association of the two IL-10 promoter gene polymorphisms with susceptibility to coronary artery disease (CAD) in Iranian population.
Subjects and methods: We used the Sequence Specific Primer-Polymerase Chain Reaction method to determine genotypes.
We also studied mRNA expression of the IL-10 gene in Iranian CAD patients using quantitative real-time PCR.
Results : There was a significant association between IL-10(819) T allele and IL-10(819) T/T genotype, and CAD (p = 0.041 and p = 0.042 respectively).
There also was a significant association between IL-10 (1082) G allele and IL-10(1082) G/G genotype, and CAD (p = 0.017 and p = 0.020 respectively).
Genotype T/T of IL-10(819) polymorphism significantly associated with the two vessel disease type (p = 0.017).
In addition, there was a significant association between IL-10(1082) G/G genotype and the three vessel disease type (p = 0.009).
IL-10 mRNA expression was significantly decreased 3.36-fold in samples with IL-10(819) polymorphism and 1.98-fold in individuals with IL-10(1082) polymorphism.
Conclusions : Our results suggest that IL-10 gene promoter polymorphisms may influence both coronary artery disease risks and severity in Iranian patients
American Psychological Association (APA)
Musavi, Sayyidah Zahrah& Salihi, Arif& Jurjani, Isa& Manzari, Rida Salihi& Farazmandfar, Touraj& Shahbazi, Majid. 2018. Association assessment of Interleukine-10 gene polymorphism and its expression status with susceptibility to coronary artery disease in Iran. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-783634
Modern Language Association (MLA)
Musavi, Sayyidah Zahrah…[et al.]. Association assessment of Interleukine-10 gene polymorphism and its expression status with susceptibility to coronary artery disease in Iran. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 1 (Jan. 2018), pp.31-35.
https://search.emarefa.net/detail/BIM-783634
American Medical Association (AMA)
Musavi, Sayyidah Zahrah& Salihi, Arif& Jurjani, Isa& Manzari, Rida Salihi& Farazmandfar, Touraj& Shahbazi, Majid. Association assessment of Interleukine-10 gene polymorphism and its expression status with susceptibility to coronary artery disease in Iran. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-783634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 34-35
Record ID
BIM-783634