Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat
Joint Authors
Husayniyan, Sarah
Rad, Abu al-Fadl Khajavi
Muhibbat, Rida
Shafii, Muhammad Nasir
Beheshti, Farimah
Rawshan, Nuaymah Muḥammadiyan
Anaeigoudari, Akbar
Parhizgar, Soghra
Khazdeir, Muhammad Rida
Soukhtanloo, Muhammad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 28, Issue 6 (31 Dec. 2017), pp.1270-1281, 12 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2017-12-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Topics
Abstract EN
Extracts of both Curcuma longa (CL) and Nigella sativa extract (NS) are reported to have protective effects on renal damage.
In this study, we investigated the protective effect of a combination of NS and CL on Adriamycin (ADR)-induced renal damage.
Forty eight rats were divided into six groups as: Control (CO), ADR, Vitamin C + ADR, CL + ADR, NS +ADR, and CL + NS + ADR.
ADR was injected intravenously on the 7th day of the study.
24-hour urine and orbital blood samples were collected on day 0, 48 hr after ADR injection and at the end of weeks 2, 3, 4, and on the 35th day.
Glomerular filtration rate (GFR) was calculated on each sample, and on the 35th day, renal index and histological changes were also evaluated.
In the ADR-treated rats, significant renal pathological changes were demonstrated compared to CO group.
The renal index and urine protein excretion significantly increased, and serum albumin and GFR in the ADRtreated rats were significantly decreased compared to CO group.
In NS + ADR group, the serum albumin significantly decreased compared to ADR group.
In CL + NS + ADR group, the urine protein excretion was lower than ADR group, and serum albumin concentration was significantly higher than ADR group.
In addition, in CL + ADR and NS + ADR groups also, the urine protein was significantly lower compared to ADR group.
This study shows that the mixed extracts of N.
American Psychological Association (APA)
Muhibbat, Rida& Shafii, Muhammad Nasir& Beheshti, Farimah& Soukhtanloo, Muhammad& Rawshan, Nuaymah Muḥammadiyan& Anaeigoudari, Akbar…[et al.]. 2017. Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 6, pp.1270-1281.
https://search.emarefa.net/detail/BIM-785628
Modern Language Association (MLA)
Muhibbat, Rida…[et al.]. Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 6 (Nov. / Dec. 2017), pp.1270-1281.
https://search.emarefa.net/detail/BIM-785628
American Medical Association (AMA)
Muhibbat, Rida& Shafii, Muhammad Nasir& Beheshti, Farimah& Soukhtanloo, Muhammad& Rawshan, Nuaymah Muḥammadiyan& Anaeigoudari, Akbar…[et al.]. Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 6, pp.1270-1281.
https://search.emarefa.net/detail/BIM-785628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1279-1281
Record ID
BIM-785628