The role of mannose-binding lectin 2 (MBL2) gene polymorphisms in adenoid hypertrophy among young children
Joint Authors
Dawud, Ali S.
Hamid, Husam Majid
Source
Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Issue
Vol. 18, Issue 3 (30 Nov. 2017), pp.267-270, 4 p.
Publisher
Egyptian Society of Ear Nose Throat and Allied Science
Publication Date
2017-11-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Topics
Abstract EN
Objective : Is to determine the role of Mannose binding lectin (MBL) 2 (SNP 49 C/T rs#5030737) gene polymorphism among patients with adenoidal hypertrophy in Iraqi population.
Methods : From July through December 2015, a total of 60 adenoid hypertrophy (study group) young child patients (35 males and 25 females) with an age between (4 and 12) years old, were enrolled in this study according to selection criteria.
A second group of otherwise healthy young child who did not have any symptoms or signs of adenoid hypertrophy were considered to be a control group.
Confirmation of adenoid hypertrophy was achieved by : clinical examination, radiological assessment of postnasal space and an endoscopic nasopharyngoscopy.
Blood samples were collected from both groups and genotyping of MBL-2 gene polymorphism was performed using traditional PCR and allele-specific technique.
Results : MBL2 gene polymorphism and allele frequencies among adenoid hypertrophy patients and their control were studied and the results showed that CC = 40 (66.7%), TT = 13(21.7%), and CT = 7 (11.6) in study group, while in control group CC = 5(8.3), TT = 9 (15%).CT = 46 (67.7%).
The P-value of genotypes (CC, TT and CT) in study groups versus the control group were P < 0.001 (highly significant), P = 0.435 (non-significant) and P < 0.001 (highly significant) respectively.
Conclusion : The difference between the MBL2 (SNP 49 C/T rs#5030737) gene polymorphism among adenoid hypertrophy patients and healthy people may indicate it could be used as an early predictive factor for children whom will be prone to adenoid hypertrophy.
The genotype CC could be considered as a risk factor while CT genotype could be considered a protective factor against adenoid hypertrophy in the current study.
A further study needed to evaluate the use of the above mentioned polymorphism as a prognostic value for adenoid hypertrophy.
American Psychological Association (APA)
Hamid, Husam Majid& Dawud, Ali S.. 2017. The role of mannose-binding lectin 2 (MBL2) gene polymorphisms in adenoid hypertrophy among young children. Egyptian Journal of Ear, Nose, Throat and Allied Sciences،Vol. 18, no. 3, pp.267-270.
https://search.emarefa.net/detail/BIM-785959
Modern Language Association (MLA)
Hamid, Husam Majid& Dawud, Ali S.. The role of mannose-binding lectin 2 (MBL2) gene polymorphisms in adenoid hypertrophy among young children. Egyptian Journal of Ear, Nose, Throat and Allied Sciences Vol. 18, no. 3 (Nov. 2017), pp.267-270.
https://search.emarefa.net/detail/BIM-785959
American Medical Association (AMA)
Hamid, Husam Majid& Dawud, Ali S.. The role of mannose-binding lectin 2 (MBL2) gene polymorphisms in adenoid hypertrophy among young children. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2017. Vol. 18, no. 3, pp.267-270.
https://search.emarefa.net/detail/BIM-785959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 269-270
Record ID
BIM-785959