Effect of androgenic anabolic steroide dianabol in liver and kidney of male albino rats

Abstract EN

Dianabol are being abused normally, Sportspersons, coaches, and doctors should be aware of their risky side effects.

Athletes used for rise performance, lean muscle bulk, muscular strength and Increases aggressiveness and sureness in addition the Adverse effects of AAS on many organs such as liver and kidney which are study now .

In this research The rats were divide in to three groups ,( 4 replicates for each) .

The first group control was orally received normal saline for such period .

while the second group (t2) and third (t3) treated groups orally received oraly dianabol suspension at concentrations 30 and 50 mg/kg/day for 8 weeks respectively.

Serious alterations of different organ systems have been attributed to long-term use of these drugs show the effect Liver tissue treated with this drug show moderate congestion , moderate sinusoidal dilatation and moderate periportal lymphocytic cell infiltration while (group2) show moderate congestion and mild periportal lymphocytic cells infiltration in addition to mild necrosis .that means increase the dose of this drug show more harmful effect on the liver.

and moderate tubular swelling.

moderate glomerular atrophy and mild bowman’s capsule thickening in the kidney tissue