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Estimation of urinary citrate, calcium and PH levels in diabetic patients and the risk of urinary stone formation in correlation with type of disease
Other Title(s)
تقدير مستوى الستريت و الكالسيوم و الدالة الحامضية في إدرار مرضى السكري و مدى علاقة خطورة تكون حصى الكلى بنوع مرض السكري
Joint Authors
Abbas, Abbas Muhsin
Kazim, Zaynab Ali
Husayn, Murtada Hafiz
Source
Issue
Vol. 11, Issue 1 (31 Mar. 2016), pp.19-30, 12 p.
Publisher
University of Thi-Qar Research and Development Department
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
- Patients
- Kidneys
- Calcium
- Hydrogen-ion concentration
- Diabetes
- Complications(Medicine)
- Diagnosis
- Citrates
- Calculi(Pathology)
Abstract EN
Objectives : This study designed to evaluate urinary value of calcium , citrate , and the PH then assess the relation between urinary calcium and citrate with fasting blood sugar and evaluate the risk of renal stones in diabetes patients dependent of their type (type 1 and type 2) .
Patients and methods :Fifty four diabetic patients selected with no history of hypertension, no heart disease , and no other disease or smoking.
Fasting blood and 24 hour urine samples were collected to evaluate fasting blood sugar, urine calcium, urine citrate , and urine PH.
Results: 30 male (55.6 %) and 24 women (44.4%) in a total of 54 patients with diabetes mellitus, aged between 20-65 years.
The statistic results of DM type are 25(46.3 %) with type 1 and 29 (53.7 %) with type 2.
F.B.S increased (11.79 ± 4.66 mmol/l ) significantly (P < 0.01) as compared to healthy individuals (4.5 ± 0.98 mmol/l).
Urine calcium significantly elevated in DM patients (6.184 ± 1.67 mmol/day ) .
Urine citrate significantly decreased ( 0.47 ± 0.57 mmol/day ) comparing with healthy individual (2.22 ± 0.55 mmol/day ).
Urine PH (4.46 ± 0.50) significantly (P < 0.05) lower than control (6.16 ± 0.38 ).
There are a positive correlation between F.B.S and urine calcium for all patients but there are adverse correlation with urinary citrate .
There are no significant differences (P > 0.05 ) in FBS and urine calcium between DM types except in urine citrate (P < 0.01 ), and urine PH (P < 0.05 ) significantly decreased in type 2.
Conclusion: Findings from this study suggest that poor control of diabetes result in increased the risk of urinary stone by causing hypercalciuria, hypocitruturia, and urine acidity .
Urine citrate concentration and PH level are more sensitive to the metabolic changes in diabetic patients and correlated with type of disease, their levels in type 2 diabetic patients are significantly lower than type 1, so both types of diabetes have relative risk of prevalent stone disease but type 2 diabetic patients predisposes to calcium Urolithiasis more than type 1.
American Psychological Association (APA)
Kazim, Zaynab Ali& Abbas, Abbas Muhsin& Husayn, Murtada Hafiz. 2016. Estimation of urinary citrate, calcium and PH levels in diabetic patients and the risk of urinary stone formation in correlation with type of disease. University of Thi-Qar Journal،Vol. 11, no. 1, pp.19-30.
https://search.emarefa.net/detail/BIM-786282
Modern Language Association (MLA)
Kazim, Zaynab Ali…[et al.]. Estimation of urinary citrate, calcium and PH levels in diabetic patients and the risk of urinary stone formation in correlation with type of disease. University of Thi-Qar Journal Vol. 11, no. 1 (Mar. 2016), pp.19-30.
https://search.emarefa.net/detail/BIM-786282
American Medical Association (AMA)
Kazim, Zaynab Ali& Abbas, Abbas Muhsin& Husayn, Murtada Hafiz. Estimation of urinary citrate, calcium and PH levels in diabetic patients and the risk of urinary stone formation in correlation with type of disease. University of Thi-Qar Journal. 2016. Vol. 11, no. 1, pp.19-30.
https://search.emarefa.net/detail/BIM-786282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 27-30
Record ID
BIM-786282