Synthesis, characterization and biological activity of new derivatives of thieno [2, 3-b] pyridine-5-carboxylic acid
Other Title(s)
تحضير و تشخيص و دراسة الفاعلية الحيوية لبعض مشتقات الثينو [b-2,3] بيريدين-5- كاربوكسيلك الجديدة
Dissertant
Thesis advisor
Comitee Members
al-Zirini, Wail Ali Hasan
al-Shahatit, Sulhi Faysal
al-Tarawinah, Salah Abd al-Rahman
University
Mutah University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Jordan
Degree
Master
Degree Date
2012
English Abstract
Ethyl 7-cyclopropyl-2-(N-arylamino)-3-nitro-4-Oxo-4,7-dihydrothieno [2,3-b]pyridine-5-carboxylate (51a-d) and Ethyl 7-cyclopropyl-2-(Narylamino)- 3-nitro-4-Oxo-4,7-dihydrothieno[2,3-b] pyridine -5-carboxylic acid (52a,d) compounds, were synthesized via palladium-catalysed amination of ethyl 2-chloro-7-cyclopropyl-3-nitro-4-Oxo-4,7-dihydrothieno [2,3-b] pyridine-5-carboxylate (49) with primary aryl amines (50a-d) ,then compounds (51a ,d) were hydrolyzed in Acidic solution.
All prepared compounds (51a-d) and (52d) were characterized by1H-NMR,13C-NMR, EIMS, HR-MS, Elemental analysis (C,H,N,S) and IR, and were consistent with proposed structures .
Compound (52d) has a weak of antibacterial activity against Gram negative bacteria E.aerogenas and Gram positive bacteria S.aureus .
Main Subjects
No. of Pages
107
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Amination of aryl halides.
Chapter Four : Result and discussion.
Chapter Five : Experimental.
References.
American Psychological Association (APA)
al-Tarawinah, Wala Mubarak. (2012). Synthesis, characterization and biological activity of new derivatives of thieno [2, 3-b] pyridine-5-carboxylic acid. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-786539
Modern Language Association (MLA)
al-Tarawinah, Wala Mubarak. Synthesis, characterization and biological activity of new derivatives of thieno [2, 3-b] pyridine-5-carboxylic acid. (Master's theses Theses and Dissertations Master). Mutah University. (2012).
https://search.emarefa.net/detail/BIM-786539
American Medical Association (AMA)
al-Tarawinah, Wala Mubarak. (2012). Synthesis, characterization and biological activity of new derivatives of thieno [2, 3-b] pyridine-5-carboxylic acid. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-786539
Language
English
Data Type
Arab Theses
Record ID
BIM-786539
